Chronological study in microanatomy of human foetal pancreatic tissue
Journal Title: Indian Journal of Clinical Anatomy and Physiology - Year 2018, Vol 5, Issue 4
Abstract
Introduction The name of pancreas derives from the Greek word The pancreas involves in diseases like diabetes mellitus and pancreatic cancer It is contains Endocrine cells or Islets of Langerhans that secrete insulin glucagon and somatostatin which regulate blood glucose levels1The exocrine pancreatic acini secretes pancreatic enzymes and alpha fetoprotein which change the expression level during development and influences development and differentiation of pancreas2Endocrine disease causes diabetes which affects at least 200 million people worldwide and this number is to be doubled by 20251 The exocrine part leads to pancreatic cancer causing about 65000 deaths in European countries which is virtually incurableAims The purpose of the current study was to investigate microanatomy Histogenesis of Pancreas in aborted fresh human foetuses without any congenital abnormality So the present study was conducted to know the development of acini and islets and their clinical correlationMaterials and Methods Foetuses aged between 12 to 40 weeks of gestational age and they were collected from Obstetrics and Gynaecology department of Kamineni Institute of Medical Sciences Narkatpally Nalgonda Dt Telangana India and Kamineni Academy of Medical Sciences and Research centre LB Nagar HyderabadThe histogenic procedures were employed at all gestational ages and were discussed with the available literature because various studies have proved that the islets of pancreas are necessary for the transplantation of pancreas but very few studies showed the importance of pancreatic aciniResults and Conclusion In the early weeks 1218 weeks the parenchyma forms primitive tubules with small lobes and lobules of acini and small spherical islets As the age advances 1824 weeks the size and number of Islets are increased with encapsulation and proliferation of acinar cellsTo conclude at the age of 1824 weeks the fetal pancreas is suitable for organ transplantation in patients with diabetes mellitus and pancreatic cancerKeywords Histogenesis Gestational period Pancreas Serous acini Islets of Langerhans Microanatomy Ducts Alpha fetoprotein AFP
Authors and Affiliations
T V. Ramani, M Pratyusha, S Saritha
Keywords
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- EP ID EP476136
- DOI 10.18231/2394-2126.2018.0126
- Views 90
- Downloads 0
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