CHRONOTHERAPEUTIC DRUG DELIVERY SYSTEM: AN EMERGING APPROACH TO TREAT CIRCADIAN RHYTHMIC RELATED DISEASE
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 8
Abstract
The research on chronotherapy has garnered interest from scientists to understand circadian rhythms and their applications in the biological system. The area of chronotherapeutics covers essential information which is helpful to move forward and solve entanglements in current drug delivery technology. Chronotherapy is the conveying drugs in the body at the target site by maintaining perfect synchronicity with circadian rhythms. The main aim of the current rhythmic research is to formulate and design a therapeutic novel system which can deliver the drug in a desired way inside the body to treat various rhythmic diseases according to their occurrence. Drug release from an ideal chronotherapeutic system should be rapid, and the release of drug from the delivery system should also be complete after a specific or defined lag time period. Recently, scientists are involved in developing chronotherapeutic drug delivery system to treat chronological diseases such as single and multiple units using an erodible, soluble or insoluble polymer coating, and stimuli regulated drug delivery systems. In this review, we focus on the elaboration of the concept of chronotherapy, main challenges ahead during its development process, current approaches and its future applications in drug delivery in the treatment of circadian rhythmic diseases.
Authors and Affiliations
Anuttam Kuila, Nagasamy Venkatesh Dhandapani, Himangshu Bhowmik, Abhishek Soni, Kammari Harish Kumar
Keywords
Related Articles
- EP ID EP567297
- DOI 10.22159/ajpcr.2018.v11i8.26169
- Views 166
- Downloads 0
EFFECTS OF DRIED LEAF POWDER OF OCIMUM SANCTUM IN HEXAMITA-INFECTED FISH ANABAS TESTUDINEUS
Objective: The prophylactic and antioxidative role of the dried powdered of Ocimum sanctum (Tulasi) was measured in Hexamita-infected fish Anabas testudineus. Method: Four groups of infected fish were kept in four separ...
The ROLE OF HERBAL ANTIFUNGAL AGENTS FOR THE MANAGEMENT OF FUNGAL DISEASES: A SYSTEMATIC REVIEW
Nowadays, fungal infection of skin is one of the most common dermatological problems worldwide. It has been investigated that 40 million people suffer from fungal infections. Superficial and subcutaneous fungal infection...
EVALUATION OF THE HISTOPATHOLOGICAL AND BIOCHEMICAL EFFECT OF ALOE VERA AQUEOUS EXTRACT ON DIABETES MELLITUS INDUCED BY STREPTOZOTOCIN IN RATS
Objective: Numerous plants have exciting pharmaceutical activities, but Aloe vera (AV) is likely to have many medicinal applications worldwide. Therefore, the present study focused on identifying the potent...
GAS CHROMATOGRAPHY-MASS SPECTROMETRIC ANALYSIS AND IDENTIFICATION OF BIOACTIVE CONSTITUENTS OF CATHARANTHUS ROSEUS AND ITS ANTIOXIDANT ACTIVITY
Objective: The main objectives of this study were analysis of the phytochemicals produced by two different Catharanthus roseus morphotypes, i.e., pink and white flowered and evaluate it morphologically and phytochemicall...
EVALUATION OF ANTIBACTERIAL, ANTIMICROBIAL, AND HYPOGLYCEMIC EFFECTS OF THE LEAVES OF EMBELIA RIBES
Objective: The purpose of this work is to evaluate the antimicrobial, antibacterial, and hypoglycemic effects of methanolic and ethanolic extracts of Embelia ribes leaves using in vitro studies.Methods: Antibacterial act...