Cisplatin-Gemcitabine Related Cardiomyopathy in Non-Small Cell Lung Cancer NSCLC Patient: A Case Study
Journal Title: Journal of Case Reports and Studies - Year 2018, Vol 6, Issue 4
Abstract
Gemcitabine is a pyrimidine analog and cisplatin is a platinum agent, they are usually combined to form a chemotherapeutic doublet used to treat different types of oncological cancers, including non-small cell lung cancer (NSCLC). Although these agents are not known to cause such events, few cases related to possible cardiotoxicity side effects have been reported ; including angina, chronic heart failure, arrhythmias, and cardiac ischemia. A 52-year-old African male presented with Stage IV lung adenocarcinoma metastatic to the bone, pleura and lymph node, EGFR wild type. Patient has a history of hypertension, diabetes, and atrial fibrillation and on rate control medications. He was treated initially with cisplatin-gemcitabine, after which he developed cardiomyopathy. This was proven by a two-dimensional echocardiography with an ejection fraction dropping from 65% to 35%. In our perspective, cardiomyopathy could be related to cisplatin-gemcitabine, which is a rare but potential risk factor for developing cardiomyopathy especially if the patient has pre-existing comorbidities that may potentiate toxicity. An instant discontinuation with close monitoring is needed. Furthermore, we suggest considering other options of chemotherapy for patients if they develop cardiac adverse events.
Authors and Affiliations
Dawoud RA
Keywords
Related Articles
- EP ID EP584876
- DOI 10.15744/2348-9820.6.405
- Views 102
- Downloads 0
Acrometastasis from a Pancreatic Primary Adenocarcinoma: A First Report in the Literature
A seventy five year male presented with acute onset right foot pain and swelling. Plain imaging revealed a lytic area in the medial and middle cuneiform bones of the right foot. Background history of resected pancreatic...
Tolerating Extreme Hyperkalemia in a Non-Compliant Dialysis Patient
Dialysis patients are known to tolerate high potassium due to the chronic hyperkalemia that is inherent in their disease. Despite this, most reports of extremely high potassium (>9 mmol/L) are in the setting of cardiac a...
Quality of Life after Accidental Major Vascular Injury and Prolonged ICU Stay - A Case Report
Survival or mortality rate is a reasonable choice of an outcome measure for critically ill patients in intensive care unit (ICU). But it is also important to assess the impact of critical illness and peri-operative compl...
Severe and Unusual domestic Violence; A Case Report and Review of Literature
Violence against women is one of the most systematic and prevalent human rights abuses in the world. Here, we aim to demonstrate a case of sever domestic violence from rural area suffering severe injuries. A 24 years old...
Severe Bone Marrow Suppression Associated with Use of Clopidogrel
A 60 year-old male presented with fever, malaise, and myalgias. The patient was admitted 3 weeks prior for acute coronary syndrome, underwent coronary stent placement, and was started on clopidogrel. He denied any chills...