Clinical and Functional Outcome of Intraarticular Platelet-Rich Plasma in Early Primary Osteoarthritis Knee Joints and Comparison of Single Vs Double Dose.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Introduction :Osteoarthritis (OA) is chronic progressive, softening and disintegration of articular cartilage and new growth of cartilage and bone at joint margins. Now a days, so many non surgicalmodalities of treatment are being developed to delay the surgery for osteoarthritis. Out of which PRP is being widely used and portrayed as a wonder drug. The purpose of this study was to evaluate Clinical and functional outcome of intraarticular platelet-rich plasma in early primary osteoarthritis knee joints and compare single vs double dose. Materials and Methods: It is a prospective randomized study conducted from Nov 2017 to Nov 2018 on 200 primary osteoarthritic knee joints, selected from the Outpatient Department of Orthopaedics, Sri VenkateswaraRamnarainRuia Government General Hospital (SVRRGGH). Clinical examination and x rays of the knee joints were done and blood sample of the patients were collected and PRP prepared in the Department of Pathology of the same institute. By computer based randomization, patients are divided into two groups group A and group B. Group A received two doses of PRP 3 weeks apart, group B received single dose of PRP. Infiltration was done in Operation Theatre under strict aseptic conditions. Patients were assessed with WOMAC (Western Ontario McMaster Universities Arthritis Index) scoring pre injection of PRP and post injection period of 1 month,3 month and 6 months. A reduction in WOMAC score is suggestive of improvement in the patient’s condition. The collected data been computed in excel and analyzed through SPSS version 2.0,EPI.INFO and the p value and mean values been obtained. Results: A Prospective study with 100 patients with bilateral primary osteoarthritis (200 knees) grade 1/2 to study clinical and functional outcome of intraarticular PRP and effect of single vs double dose. Out of 200 knees, 70 were males, 130 were females, 97 were grade 1, 103were grade 2. According to Womac score, grade of result in group A – poor - 3, fair - 8, good - 41, excellent – 48. Group B - poor - 7, fair - 27, good - 58, excellent – 8. On assessing the results, there is a significant improvement in WOMAC score of all the patients and the results sustained for 6 months. Patients showed better results with two doses of PRP when compared with patients who received single dose. Though clinically better results are seen in grade I knee joints than grade II knee joints, the difference is statistically not significant. There is no significant difference between males and females in group A and group B with grade 2 OA, but females showed better results than males in group A and group B with grade 1 OA. Conclusion: We can safely conclude that Intraarticular Autologous PRP infiltration in early primary Osteoarthritis (Grade I and Grade II) of Ahlback’s radiological grading gives relief from pain, stiffness and improves physical functionality without major side effects and can be used as modality of treatment. There is significant difference between single dose and double dose regimen, we conclude that double dose offers additional advantage.
Authors and Affiliations
K. Santhosh, S. Sreenivasareddy, P. Ravishankar, R. Venkat, D. L. Venkatesh
Keywords
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- EP ID EP553737
- DOI 10.9790/0853-1803015260.
- Views 58
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