Clinical and histological evaluation of toluidine blue positive and negative stained oral mucosal lesions
Journal Title: Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology - Year 2016, Vol 2, Issue 3
Abstract
Introduction: Screening of suspicious oral precancerous lesions can aid in early detection of oral cancer thus reducing the mortality and morbidity associated with this condition. Incisional biopsy remains a gold standard for diagnosis of oral potentially malignant disorders. Toluidine blue is a basic metachromatic stain that demonstrates affinity for DNA and RNA. It offers a potentially simple, inexpensive, and sensitive chair-side solution for screening of early oral squamous cell carcinoma and highgrade dysplasias. The aim of this study was to assess the reliability of toluidine blue stain as clinical screening test, for presence of epithelial dysplasia in oral mucosal lesions. In this study, biopsy was done in patients with oral pre-malignant lesions to relate their toluidine blue status to outcome as well as to conventional histopathologic features. Method: Study Group consisted of 51 patients with potentially malignant oral mucosal lesions like homogenous leukoplakia (20), non-homogenous leukoplakia (16), erythroplakia (6), oral submucous fibrosis (5) and tobacco pouch keratosis (4). Patients were subjected to toluidine blue vital stain and were observed for positive and negative staining. Biopsy was taken from both toludine blue positive as well as negative lesions and graded for epithelial dysplasia to analyze the role of toludine blue staining in selecting lesions requiring biopsy.
Authors and Affiliations
Parul Khare Sinha, Madhvika Patidar, Vineet Raj, Shaleen Chandra, Nitin Agarwal
Keywords
Related Articles
- EP ID EP241947
- DOI -
- Views 120
- Downloads 0
Bacteria in oral carcinogenesis
Cancer is a subject that has got enormous depth and we clinicians are still searching for the end point The multi centric etiopathogenesis of cancer makes it a field of enormous research Bacteria meanwhile have been seen...
Mucocutaneous Angiomyolipoma of Premaxillary region Masquerading as Lipoma: a known but rare occurrence
Angiomyolipomas (AML) are distinctive benign mesenchymal tumors seen predominantly in the kidney. Majority (80%) of these tumors are sporadic, while remaining 20% of them are associated with tuberous sclerosis (TS). Extr...
Evaluation of systolic and diastolic blood pressure, pulse rate and SPO2 levels pre and post dental extraction under local anesthesia
Aim To evaluate the changes in blood pressure pulse rate and SpO2 pre during and post extraction procedure under local anesthesiaMaterials and MethodA total of 150 patients were included in the study Pulse oximeter was p...
Smart app for smart diagnosis: Whatsapp a bliss for oral physician and radiologist
Background: Health care has changed dramatically by the scientific blend of telecommunication and smart phones. The result of which is the teledentistry, an innovative field that involves the exchange of clinical informa...
A Case Report of Aneurysmal Bone Cyst of the Mandible
Aneurysmal bone cyst (ABC) is a rare benign lesion of bone, which represents less than 1% of all the bone cysts biopsied. It is generally noted in long bones and spine and is less common in the craniofacial skeleton incl...