CLINICAL CASE OF PROGRESSIVE SUPRANUCLEAR PARALYSIS (STEELE-RICHARDSON-OLSHEWSKI SYNDROME)
Journal Title: International scientific journal Science and Innovation - Year 2024, Vol 3, Issue 6
Abstract
Progressive supranuclear palsy is a rare neurodegenerative disease affecting the central nervous system [1], characterized by progressive impairment of voluntary eye movements, bradykinesia, muscle rigidity with simultaneous dystonia of the axial muscles, and dementia [1]. PSP, also known as Steele-Richardson-Olszewski syndrome, affects men and women equally [5]. In the early stages, patients with PSP often have trouble walking, balancing, and falling backward, often many times a day; some find it difficult to walk and feel like their feet are glued to the floor; patients experience difficulty with eye movements, especially downward gaze, as well as difficulty opening the eyes[5]. This disease is an atypical form of Parkinson's disease. In this disease, degeneration of neurons in the basal ganglia and brain stem is observed with the presence of neurofibrillary tangles containing excessively phosphorylated tau protein[1]. Progressive supranuclear palsy with Richardson syndrome (PSP-SR): classic progressive supranuclear palsy with progressive supranuclear ophthalmoplegia and severe balance impairment (most common form, in ≥ 70% of cases) [3]. At the moment, the etiology of this pathology is unknown. Patients with PSP have a poor prognosis, which is associated with early cognitive impairment, dysphagia, and death within 10 years due to aspiration.
Authors and Affiliations
Aripova N. F. , Omonova U. T.
Keywords
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- EP ID EP741515
- DOI 10.5281/zenodo.12599829
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