Clinical effects of half- and full-dose abatacept are equivalent
Journal Title: IP International Journal of Orthopaedic Rheumatology - Year 2016, Vol 2, Issue 1
Abstract
Objectives: To compare the clinical effect and cost effectiveness of half- and full-dosage abatacept in patients aged over 65 years diagnosed with rheumatoid arthritis. Methods: Sixty-three elderly patients aged > 65 years with rheumatoid with abatacept were enrolled from four hospitals. Disease Activity Score using C-reactive protein (DAS 28-CRP) were evaluated as well as blood, urine, and radiographic analyses before and 52 weeks after abatacept administration. Results: DAS 28-CRP decreased from 5.1 ± 0.9 to 2.6 ± 1.0 for half-dosage and from 4.6 ± 1.3 to 2.8 ± 0.9 for full-dosage abatacept, but the differences were not significant. Clinical improvement using DAS 28-CRP was similar in patients aged 65-74 years and those aged > 75 years. Conclusions: Half-dosage abatacept exhibited the same clinical effect and cost effectiveness of full-dosage of abatacept. And age was not a risk factor for ABT treatment.
Authors and Affiliations
Yasunori Itoh, Wataru Shimada2, Masato Kamiya, Masakatsu Saitoh4, Osamu Matsuo, Hiraku Kikuchi
Keywords
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