Clinical efficacy analysis on leflunomide and Shenyitong Granule combination in treatment of mesangial proliferative glomerulonephritis
Journal Title: 现代药物与临床 - Year 2012, Vol 27, Issue 2
Abstract
Objective To observe the clinical efficacy of leflunomide and Shenyitong Granule combination in treatment of mesangial proliferative glomerulonephritis. Methods Sixty-five patients were randomly divided into the leflunomide group (25 cases), leflunomide plus Shenyitong Granule group (20 cases), and Shenyitong Granule group (20 cases). Clinical symptoms, signs, urine, 24 h urinary protein excretion, serum albumin (ALB), urinary red blood cell count, blood count, blood urea nitrogen, serum creatinine (Ser), alanine aminotransferase, and aspartate aminotransferase were tested as well as the adverse reactions were observed during the treatment. Results There were no significant difference between leflunomide group and Shenyitong Granule group (P>0.05). Six months later, the efficacy of leflunomide plus Shenyitong Granule group (100%) was better than Shenyitong Granule group (P<0.05) and the leflunomide group (P<0.05). Conclusion In combination of leflunomide and Shenyitong Granule are effective in treatment of mesangial proliferative glomerulonephriti with little adverse reaction and fewer side effects, which is worth of spreading in clinic.
Authors and Affiliations
CAO Jin-neng
Keywords
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