Clinical Evaluation of Intrathecal Dexmedetomidine as an Adjuvant to Bupivacaine in Patients of Abdominal Hysterectomy Under Spinal Anaesthesia
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 4
Abstract
This was a prospective randomized double blind study was conducted to evaluate Dexmedetomidine as an adjuvant with Bupivacaine (Bupivacaine 0.5% - Heavy for spinal anesthesia) intrathecally in patient undergoing abdominal hysterectomy surgery. Aim and Objectives: 1. To evaluate the efficacy of Inj. Dexmedetomidine as an adjuvant to Inj. Bupivacaine (Heavy 0.5%) for Spinal anaesthesia. 2. To know the onset, duration & quality of sensory & motor block of spinal anaesthesia. 3. To know the hemodynamic stability & side effects of the drug under study. Methods: A total of 60 female patients’ age between 35-70 years classified as ASA grade I and II were randomly divided into two equal groups scheduled for abdominal hysterectomy under spinal anesthesia. The dose of spinal anesthesia drug in Group I was 3.5 ml Bupivacaine with 0.05 ml (5μg) Dexmedetomidine and in Group II was 3.5 ml Bupivacaine with 0.05 ml Normal Saline. The onset of sensory and motor block, duration of sensory and motor block, haemodynamic stability, quality of surgical anesthesia, intraoperative complications, postoperative analgesia and side effects were recorded. Results: In Group I, early onset of sensory and motor block was noted as compared to Group II. The duration of sensory and motor block was significantly longer in Group I than Group II. The hemodynamic stability was observed in Group I. The quality of anesthesia was excellent in group I. The requirement of intraoperative sedation was significantly less in Group I when compared with Group II. The postoperative analgesia duration was significantly longer in Group I than Group II with minimal postoperative side effects. Conclusions: Inj. Dexmedetomidine 5 μg seems to be an excellent alternative adjuvant with spinal Bupivacaine (Heavy 0.5%) to increase duration of postoperative analgesia of spinal anesthesia in surgical procedure like abdominal hysterectomy.
Authors and Affiliations
Dr. Rajesh V Nagmothe
Keywords
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