Clinical evaluation of serum transaminases and plasma glucose levels in patients with oral lichen planus: A hospital based study
Journal Title: Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology - Year 2017, Vol 3, Issue 2
Abstract
ntroduction: The association of lichen planus with chronic liver disease and diabetes mellitus has been extensively studied, but the conclusions are often controversial. Aim of the study was to assess the relationship of lichen planus with liver function status and diabetes mellitus in patients from Malabar region of Kerala. Materials and Method: The study was performed on 50 patients with oral lichen planus (OLP) as study group and 50 control group cases. Routine blood test was carried out in all the patients and analyzed for ALT(Alanine transaminase), AST(Aspartate transaminase) levels, fasting plasma glucose(FPG) and random plasma glucose levels (RPG). The values of ALT and AST levels ≥ 40 IU/l were categorized as impaired liver function. Subjects with FPG ≥ 126 mg/dl and/or RPG ≥200 mg/dl were considered as having diabetes mellitus. Results: FPG/RPG levels were elevated in 17 cases with OLP while only 10 control group cases had increased levels (p > 0.05). Regarding AST and ALT levels, it was elevated in 23 cases (46 %) and in 10 cases (20 %) of the study group and control group, respectively. These differences were statistically significant (P <0.006). Out of 16 erosive forms, 11 cases showed elevated AST/ALT levels and among 34 non-erosive cases, only 12 patients showed elevated AST/ALT levels (p < 0.05). Conclusion: Elevated transaminases and plasma glucose levels can be associated with oral lichen planus according to this study. However, larger sample size studies, evaluating different parameters are required to establish the hepatic changes and impaired glucose function in OLP.
Authors and Affiliations
Merrin Jose, Anita Balan
Keywords
Related Articles
- EP ID EP294834
- DOI 10.18231/2395-6194.2017.0021
- Views 113
- Downloads 0
Epithelial myoepithelial carcinoma of parotid gland-a case report
Epithelial-Myoepithelial Carcinoma is a rare malignant salivary gland neoplasm. It is also known as adenomyoepithelioma. It accounts for less than 1% of all salivary gland neoplasms. This unusual salivary gland tumors is...
Solid variant of adenoid cystic carcinoma of oral cavity: A diagnostic difficulty in
Introduction Adenoid cystic carcinoma ACC is a malignant tumor affecting mainly the salivary glands It can also occur in other sites like breast and skin It is important to diagnose adenoid cystic carcinoma at its early...
Calcifying epithelial odontogenic tumor without calcification: A rare entity
Pindborg in 1955, for the first time described four cases of a rare benign odontogenic tumor. Shafer et al called this entity Pindborg tumor. This was later referred to as the calcifying epithelial odontogenic tumor. It...
Ameloblastoma: A case report
Ameloblastoma is an odontogenic neoplasm whose significance lies in their impending nature to grow to huge size resulting in bone distortion. Unicystic ameloblastoma (UA) is a variation of the solid or multicystic amelob...
Keratocystic tumor in mandibular body region
Odontogenic keratocyst(OKC) are developmental, non-inflammatory, chronic odontogenic cysts of epithelial origin derived from remnants of the dental lamina with a biologic behavior similar to that of benign neoplasm. The...