Clinical Features and Treatment Strategy of Vasculitis-Associated Diffuse Alveolar Hemorrhage
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 11, Issue 1
Abstract
Objectives: To summarize the clinical features and diagnostic approach of patients with vasculitis-associated diffuse alveolar hemorrhage (DAH). To investigate the optimal therapeutic strategy and highlight the effective corticosteroid dose and timing. Methods: A retrospective chart review of the patients who were admitted to the intensive care unit (ICU) due to vasculitis-associated DAH was performed. Patient characteristics, clinical manifestations, the diagnosis of underlying etiology, treatment, and outcome were collected. Results: During January 2015 to December 2017, seven vasculitis-associated DAH patients were reviewed. The mean age ± SD was 53.4 ± 18.2 years. Five patients (71%) were female. DAH was the initial presentation in all seven patients (100%). All patients required immediate mechanical ventilation. As first line therapy, methylprednisolone (MTP) pulse therapy combined with cyclophosphamide pulse therapy were administered to all patients. Six patients survived. Four of them received MTP and cyclophosphamide pulse therapy shortly after admission (mean 1.6 days, range: <1-3days) showed good response to therapy and were extubated successfully within ten days after ICU admission. Conclusion: Vasculitis-associated DAH is a fatal disorder. Once the diagnosis of DAH is confirmed, intensive administration of MTP and cyclophosphamide pulse therapy initiated within 3 days of admission provide good survival and pulmonary outcome.
Authors and Affiliations
Ya-Chih Tien, Ying-Ming Chiu, Ming-Hui Hung, Jin-Lan Shen, Chih-Ming Lin
Keywords
Related Articles
- EP ID EP587236
- DOI 10.26717/BJSTR.2018.11.002057
- Views 189
- Downloads 0
Children and Infant’s Vision and Measure for Detecting Congenital Eye Diseases
A baby’s vision goes through many changes during their first year of life. Knowing the milestones development of vision is what you can do to help your baby as well as can help you watch and enjoy on it. The pediatrician...
Concept to the Problems of Transfusion of Albumin
The advantages of albumin over less costly alternative fluids continue to be debated. Many scientific articles were devoted to the clinical analysis of the use of albumin in acute illness as well as its comparison with o...
Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment
Objective: Collect published research articles on the desired topic and summarizes their findings in an evaluation of the preservative and therapeutic potential of Rosmarinus officinalis. Design: The research articles us...
Child Genius of Biomolecules: Exosomes and Perspective on Lung Cancer
Exosomes are bioactive receptors which is indirectly originating from the cell membrane. The dimensions vary between 50-140 nm. The most important features distinguishing exosomes from other extracellular vesicles (micro...
Assessment and Alleviation of Lumbopelvic Pain and Pelvic Floor Dysfunction
Because of the time- and labor-intensive nature of the proposed study, a 5-week pilot test consisting of 10 subjects was implemented to determine if protocol modifications were necessary and if the full 60-subject study...