Clinical-Laboratory and Echocardiographic Indicators in Patients with Chronic Heart Failure and Anemic Syndrome
Journal Title: Український журнал медицини, біології та спорту - Year 2017, Vol 8, Issue 6
Abstract
Anemia is one of the serious complications of chronic heart failure (CHF) and is associated with an increased risk of mortality and high hospitalization rates. The purpose of the study was to estimate the clinical- laboratory and echocardiographic indicators in patients with chronic heart failure and anemic syndrome. Materials and methods. This study involved 150 male patients aged 35–78 years (median 58 years) diagnosed with chronic heart failure (CHF) on the background of coronary heart disease (stable angina and prior myocardial infarction). IHD diagnosis was made based on exercise testing, coronary angiography, electrocardiography, echocardiography. The diagnosis of anemia was confirmed at the concentration of hemoglobin less than 110 g/l. General clinical examinations, laboratory (integral indices of endogenous intoxication, bilirubin, aspartate aminotransferase, alanine aminotransferase, urea, creatinine) and echocardiographic (left ventricular ejection fraction, heart chambers in diastole, left ventricular hypertrophy and geometric remodeling: normal, concentric remodeling, concentric hypertrophy, eccentric hypertrophy) investigations were performed. Statistical analysis was done using Statistica for Windows 5.0 program. Data are presented as the median [lower-upper quartiles], comparisons between groups were made using the Mann-Whitney U-test. Categorical data were assessed using the Fisher exact test, the correlation between variables – by Kendall's correlation test. Results. Patients were divided into two groups: group 1 – 40 (27%) patients with CHF and anemic syndrome and group 2 – 110 (73%) patients with CHF without anemic syndrome. It was estimated, that the patients of two groups did not differ significantly in age, presence of any arrhythmia, previous Q-infarction, diabetes mellitus, obesity. According to correlation analysis results a significant correlation has been found between hemoglobin and indices of endogenous intoxication: leukocyte index of intoxication (τ = –0,13; р = 0,03), leukocyte shift index (τ = -0,15; р = 0,01), aspartate aminotransferase (τ = -0,31; р<0,005), alanine aminotransferase (τ = -0,28; р<0,005); between hemoglobin and left ventricular ejection fraction (τ = 0,16, р = 0,007), left ventricle end-diastolic diameter (τ = -0,14, р = 0,02), left ventricular mass index (τ = 0,12; р = 0,03). Significantly (р<0,05) higher level of endogenous intoxication (leukocyte index of intoxication, leukocyte shift index, aspartate aminotransferase, alanine aminotransferase), lower values of left ventricular ejection and tendency (р<0,1) for higher values of left ventricle end-diastolic diameter, left ventricular mass index have been found in patients with CHF and anemic syndrome compared without anemic syndrome. Conclusions. The presence of anemia syndrome in patients with CHF is associated with higher indices of endogenous intoxication, with systolic dysfunction and left ventricular dilatation, predominance of eccentric dilated hypertrophy and decreased left ventricular mass index, which is important to consider in diagnostic process and treatment.
Authors and Affiliations
A. Filipyuk, V. Zenin
Keywords
Related Articles
- EP ID EP275488
- DOI -
- Views 97
- Downloads 0
Dynamics of the Blood Serum Fractalkine Content in Experimental Gastroenterocolitis
Recent studies have demonstrated that members of the chemokine family play a pivotal role in modulating migration of immune cells. They also contribute to various physiological and pathological processes, including embry...
ДОСЛІДЖЕННЯ ІНТЕНСИВНОСТІ ПОЛ, ВМІСТУ ВІТАМІНУ С, СУКЦИНАТДЕГІДРОГЕНАЗНОЇ АКТИВНОСТІ У МІТОХОНДРІЯХ НАДНИРКОВИХ ЗАЛОЗ ЗА УМОВ ЕКСПЕРИМЕНТАЛЬНОЇ НЕФРОПАТІЇ ТА ЗАСТОСУВАННЯ ВІДНОВЛЕНОГО ГЛУТАТІОНУ
Показано, що за умов експериментальної нефропатії зростає швидкість утворення ТБК-активних продуктів як спонтанним, так і аскорбат-індукованим шляхом і знижується вміст аскорбінової кислоти в гомогенаті наднирників щурів...
КАДРОВЕ ЗАБЕЗПЕЧЕННЯ ПАТОЛОГОАНАТОМІЧНОЇ СЛУЖБИ УКРАЇНИ (АНАЛІЗ ПОКАЗНИКІВ ЗА 2007–2016 РОКИ)
Для ефективного проведення реформи медичної галузі України насамперед необхідний аудит фактичного стану патологоанатомічної служби та її ресурсів. Поставлено за мету проаналізувати кадрове забезпечення патологоанатомічно...
THE LEVEL OF ADAPTIVE STRENGTH OF SCHOOL AGED CHILDREN’S ORGANISM (7–10 YEARS) WITH SCOLIOSIS
The aim of the paper was to study the level of adaptive strength of school aged children’s organism of (7–10 years) based on the absolute and relative number of key populations of immunocompetent cells. It was examined t...
Wave Structure of Heart Rhythm in Women under the Psychoemotional Pressure
Features of the wave structure of heart rate variability (HRV) usually reflect the dynamics of regulatory processes in humans and animals. However, most of the studies on physiological characteristics are conducted on me...