Clinical Profile and Etiology of Cirrhosis of Liver In Tertiary Care Hospital, AP.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 9
Abstract
Introduction: Cirrhosis is defined by the World Health Organization (WHO) as a diffuse process characterized by fibrosis and the conversion of normal liver architecture into structurally abnormal nodules.3,4 The progression of liver injury to cirrhosis may occur over weeks to years. Chronic liver diseases and cirrhosis result in 26,000-35,000 deaths each year in the United States (US). Cirrhosis is the 9th leading cause of death in the US and is responsible for 1.2% of all US deaths.5 Materials and Methods: Three hundred consecutively diagnosed adult cirrhosis patients were prospectively studied at the Department of Gastroenterology, Kurnool Medical College and hospital, a tertiary care hospital of AP from June 2016- May 2017 for their clinical characteristics, prognosis and mortality at one month Results: Commonest age group was 35-54years, mean age 45.8+ 10.4 years; M: F ratio 7.5:1. Symptoms were ascites (74.3%), gastrointestinal bleeding (43.4%), jaundice (36.3%), low urine output (31%) and altered sensorium in 23%. 37.1% patients had severe malnutrition. Aetiology were alcohol related (72.2%), HBV (8.9%), HCV (3.2%), Autoimmune Hepatitis (0.9%), Cryptogenic cirrhosis (17.2%) and NASH (1%). Complications were ascites (78.6%), variceal bleeding (43.4%), hepatic encephalopathy (21.6%), Spontaneous bacterial peritonitis 4.2%, Hepatorenal syndrome (2.7%) and Hepatocellular carcinoma (1.3%). 50% had Child C disease, 83% had MELD between 10-29 and APRI (AST to Platelet ratio index) >2.5 in 38.5% patients. Mortality was 7.8% and highest among alcoholic cirrhosis (6.8%). Conclusion: Cirrhosis is common in the most productive age and the commonest cause was alcohol cirrhosis which is preventable through proper education and legislation. Proper awareness will lead to prevention of long term morbidity.
Authors and Affiliations
Dr. B. Shankara Sharma, Dr. P. Swarupa Rani
Keywords
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- EP ID EP395566
- DOI 10.9790/0853-1709135861.
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