CLINICAL PROFILE AND HISTOPATHOLOGICAL CORRELATION OF HANSEN’S DISEASE AMONG PATIENTS ATTENDING A PRIVATE MEDICAL COLLEGE HOSPITAL IN TAMILNADU- A RETROSPECTIVE STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 87
Abstract
BACKGROUND Leprosy is a treatable chronic infectious disease, prevalent in South East Asian countries, especially India. Skin biopsy is an important tool in diagnosing leprosy and determining the type of leprosy. Before labelling a patient as a case of leprosy and starting multidrug treatment for particular type, the clinical findings should be correlated and confirmed with histopathological examination and bacteriological index of skin biopsy. The objective of this study is to find out the clinical profile and histopathological correlation of Hansen’s disease among patients attending a private medical college in Tamilnadu. MATERIALS AND METHODS A retrospective descriptive study was designed to collect clinical, bacteriological and histopathological details of leprosy patients from the case sheets and leprosy registers (from May 2010 to May 2017). The data pertaining to age, sex, clinical diagnosis, bacteriological index and histopathological diagnosis of leprosy, patients were tabulated in an Excel sheet and statistical analysis was done using SPSS V21. RESULTS In the present study, 113 untreated clinically diagnosed cases of leprosy were studied and analysed. There were 81 male patients and 32 female patients with age range from 9 years to 80 years. The most common clinical diagnosis was BT Hansen in 44 patients (38.9%) followed by LL Hansen (34.5%), BL Hansen (8.8%), TT Hansen (7.1%), BB Hansen (5.3%), pure neuritic Hansen (2.7%), histoid Hansen (1.8%) and indeterminate Hansen in 1 patient (0.9%). Slit skin smear was positive in 54.9% of patients and negative in 45.1% of patients. Considering the correlation between the clinical and histopathological diagnosis, maximum percentage of agreement (100%) was seen in LL Hansen and the least level of agreement (11.11%) was noted with indeterminate type of Hansen, i.e. cases were diagnosed more on histopathological examination rather than on clinical examination. CONCLUSION This study revealed that the histopathological examination along with bacteriological index should be carried out in all cases of leprosy to arrive at a definite diagnosis and also to classify the disease for appropriate multidrug therapy regimens.
Authors and Affiliations
Rajalakshmi R, Balasubramanian N, Seethalakshmi R. S
Keywords
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- EP ID EP277714
- DOI 10.14260/jemds/2017/1313
- Views 67
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