Clinical Profile and Therapy of Hepatocelluar Carcinoma at a Tertiary Care Institute from South India: A Retrospective Study of 182 Patients
Journal Title: Indian Journal of Cancer Education and Research - Year 2017, Vol 5, Issue 1
Abstract
Objective: To study the clinical profile and therapy of hepatocellular carcinoma (HCC) at a tertiary care institute in Andhrapradesh, Southindia. Methods: Data analysis of HCC patients enrolled in between 2000 and 2015. HCC was diagnosed according to EASL criteria-USG/CT/MRI of the abdomen and/or serum alpha-fetoprotein and/or histology (where indicated). Barcelona Clinic Liver Cancer (BCLC) staging was done. Results: We registered 182 HCC patients [males 162 (89%), mean age 57.5 ± 12.1 years]. An “Early Peak” (17%) was detected in 28-40 yr age group. The etiology of HCC was: Hepatitis B virus 70 (35.7%), Hepatitis C virus 05 (2.74%). Serum -fetoprotein was >500 ng/ml in 43.8% and very high (>5000-100 000) in 30.6%. Classical features on triple phase CT in 80% with an average tumor size of (7.3 ± 2.1 cm), Portal vein invasion was seen in 40% and distant metastases in 11%. Majority of the patients (79.6%) were BCLC stage C and D. Biochemical: Thrombocytopenia (60%), anaemia in 30%, and 80% had an elevated alkaline phosphatase levels. Therapy was offered to 127 (69.78%) patients.Treatment given was as follows: Surgical resection (n=36 19.78%); Chemotherapy, both oral and iv (n=91 19.78%), and Sorafenib (n=36 19.78%), Best supportive care (n=55 30.22%), but survival data was not available due to lack of adequate followup. Conclusions: Hepatitis B infection is the predominant cause for HCC. Diagnostic range serum -fetoprotein was detected in only 43.8% of study patients but its level correlates well with the disease burden, outcome. An “Early Peak” was observed in 28-40 year age group. Majority of the patients present with advanced disease, precluding the curative therapies. Universal immunization with hepatitis B vaccination will reduce the HBV infection rates & in part HCC burden in near future.
Authors and Affiliations
Venkatesh M.
Keywords
Related Articles
- EP ID EP459821
- DOI 10.21088/ijcer.2321.9815.5117.5
- Views 95
- Downloads 0
Sebaceous Gland Carcinoma of Upper Eyelid with Parotid Metastasis: A Case Report
Sebaceous gland carcinoma is a rare malignancy which usually arises from periocular region. It accounts of 1–5.5% eyelid malignancies and represents third most common eyelid malignancy. It mostly occurs in elderly women...
Cytological Grading of Breast Carcinoma on FNAC & Correlation with Histological Grading on Excised Specimen
Background: With the advent of fine needle aspiration cytology (FNAC), the approach to diagnosis and management of breast lesions has been revolutionized. Assigning a tumor grade to breast cancer provides important progn...
A Study to Evaluate Effectiveness of Application of Ice Cubes on Oral Mucositis among Clients Receiving Cancer Chemotherapy in Yashoda Hospitals, Twin Cities, A.P.
A Study To Evaluate Effectiveness of application of ice cubes on oral mucositis among clients receiving cancer chemotherapy in Yashoda Hospitals, twin cities, A.P. This study was undertaken by Miss. Sunitha Elizabeth Cha...
Can Accurate Pre Operative Assessment of Axillary Lymph Node in Breast Cancer Avoid Axillary Dissection?
Background: The Axillary Lymph node status is of paramount importance in staging, treatment planning, prognosis and survival in Breast Cancer. Hence appropriate investigating criteria for AXLN assessment, which is easy,...
Clinical Profile and Therapy of Hepatocelluar Carcinoma at a Tertiary Care Institute from South India: A Retrospective Study of 182 Patients
Objective: To study the clinical profile and therapy of hepatocellular carcinoma (HCC) at a tertiary care institute in Andhrapradesh, Southindia. Methods: Data analysis of HCC patients enrolled in between 2000 and 2015....