Clinical Profile of Granuloma Brain: A Prospective Study
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 2
Abstract
Introduction: Granuloma of the central nerve system is the most common radiological abnormality seen in patients with acute onset seizures in India. Neurocysticercosis (NCC) and tuberculoma are the most common causes of this granuloma. Aim: To study the clinical feature of granuloma brain and the effect of treatment on follow-up. Materials and Methods: Patients presenting with radiological evidence of single ring enhancing lesions are taken up for study. Physiological calcifications, calcified granulomas, patients with primary malignancy, and HIV were excluded. Results: Granuloma in more common in the age group from 11 to 30 years with female predominance. Focal seizures are common and parietal lobe is the most common location. Perilesional edema in more common in tuberculoma. Tuberculoma has a thick and irregular wall. Patients with NCC were treated with albendazole, steroid, and antiepileptic drugs (AEDs), patients with tuberculoma were treated with antituberculous therapy, steroids, and AEDs. Follow-up imaging at 6 and 12 months showed complete resolution of cysticercosis granuloma and tuberculoma in most of the patients. Conclusion: Focal seizures are the most common seizure type followed by generalized seizures. Majority of the granuloma occurred in parietal lobes. Follow-up computed tomography at 6 and 12 months revealed complete resolution of lesions in most of NCC patients and resolving lesions in most of the tuberculoma patients.
Authors and Affiliations
A Thomas Edwin Raj
Keywords
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