CLINICAL PROFILE OF HAEMOPHILIA PATIENTS OF UPPER ASSAM- A HOSPITAL-BASED STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 37
Abstract
BACKGROUND Haemophilia is a rare condition where patients present with abnormal bleeding and other complications of bleeding due to genetic or acquired deficiency of coagulation factor VIII (Haemophilia A) or Factor IX (Haemophilia B). Aims and Objectives- We have studied the clinical profile of haemophilia patients who have come to our tertiary medical centre for hospitalisation with some complication. MATERIALS AND METHODS All patients who were admitted in the Department of Medicine and Paediatrics with Haemophilia were included in the study. Detail clinical and family history was taken followed by physical examination and necessary investigations. Factor replacement was done using our institutional protocol, which is based on the Significant Resource Constraint Guidelines of Haemophilia Federation India. RESULTS A total of 79 haemophilia patients were studied with 94.9% males and 4 females; 74.7% were below the age of 20 years and 78.5% were known haemophilia patients, whereas 21.5% were newly diagnosed; 64.6% patients had a definite family history; 79.7% were factor VIII deficient and 20.3% were factor IX deficient; 47 (74.6%) patients had severe factor VIII deficiency, 12 (19%) patients had moderate factor VIII deficiency and 4 (6.4%) patients had mild factor VIII deficiency; 11 (68.7%) patients had severe factor IX deficiency. Out of the 57 patients who presented with joint bleed 38 (67%) had knee joint involvement, 16 (28%) had ankle joint involvement, 13 (22.8%) had wrist involvement, 8 (14%) had elbow involvement and 3 (5.3%) had shoulder joint bleed. Out of the 19 cases of intramuscular bleed, 13 (68.4%) patients had psoas bleed; 43 (75.4%) patients had multiple joint involvement; 7 (12.3%) patients both joint bleed and intramuscular bleed; 68.4% patients had joint deformity. Out of the four females with mild-to-moderate factor VIII deficiency, two had joint bleed and two had uncontrolled menstrual bleed. CONCLUSION Most of our patients were below 20 years (74.7%) and haemophilia A (79.7%). One-third of them did not have a family history. Most of them had a severe factor deficiency and knee joint was the most common joint to bleed. Two-third of the patients had joint deformity.
Authors and Affiliations
Anupam Dutta, Taniya Sarkar Dutta, Pranoy Dey
Keywords
Related Articles
- EP ID EP210724
- DOI 10.14260/Jemds/2017/645
- Views 85
- Downloads 0
ACUTE MYELOID LEUKEMIA-M3V WITH DEEP VEIN THROMBOSIS, A RARE PRESENTATION
Early diagnosis of acute promyelocytic leukemia (APL) is essential because of its associated life threatening coagulopathy. Among patients with acute leukemia, incidence of thrombosis is highest in acute promyelocy...
FAIL TO RETRIEVE GALLSTONES IN LAPAROSCOPIC CHOLECYSTECTOMY- A STUDY
BACKGROUND Gallstone spillage during laparoscopic cholecystectomy is not uncommon and despite all precautions and adoption of safety measures spilt gallstone remain unretrieved. We are trying to document the incidence of...
CLINICAL STUDY OF ELECTROCARDIOGRAM CHANGES IN DIFFERENT TYPES OF CEREBROVASCULAR ACCIDENTS AND PROGNOSTIC SIGNIFICANCE
BACKGROUND AND OBJECTIVES Stroke is one of the most common causes of death worldwide. People who suffer cerebrovascular accidents also have an abnormality in the hearts electrical cycle are at a higher risk of...
INTERSTITIAL BRACHYTHERAPY IN THE MANAGEMENT OF UTERINE CERVICAL CANCER- SINGLE INSTITUTIONAL STUDY
BACKGROUND The objective of this study is to report the clinical outcome of patients with carcinoma cervix treated by radiation therapy including brachytherapy (BT), using template based Interstitial Brachytherapy (ISBT)...
GASTROPROTECTIVE EFFECT OF CURCUMA LONGA LINN. AGAINST ETHANOL INDUCED GASTRIC ULCER IN RATS
BACKGROUND Peptic ulcer is a global health problem, both in terms of morbidity and mortality. There are many treatment strategies for tackling this disease including proton pump inhibitors, H2 receptor antagonists, ulcer...