Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning
Journal Title: Istanbul Medical Journal - Year 2019, Vol 20, Issue 6
Abstract
Introduction: This study aimed to investigate lactate and lactate clearance and to determine the feasibility of the use of lactate clearance for assessing treatment efficacy in carbon monoxide (CO) poisoning. Methods: All patients aged 18 years and older with CO intoxication between 01.06.2016 and 28.02.2018 were included. COHb levels, initial (lactate-1), and post-treatment control lactate (lactate-2) levels, lactate clearance, type of treatment [normobaric, or hyperbaric oxygen therapy (HBOT)] were recorded. The receiver operating characteristic curve was configured to establish a cut-off point of initial lactate level with the calculated area under the curve (AUC) to predict the need for HBOT. Results: A total of 103 patients were included. There was a moderate correlation between COHb and lactate-1 (r=0.49; p<0.001) and a weak correlation between COHb and lactate clearance (r=0.291; p=0.003). A significantly higher increase was observed in lactate clearance in the HBOT group (p=0.017). The AUC value of initial lactate in predicting the need for HBOT was 0.708. Conclusion: The initial lactate level and lactate clearance are rapidly performed and effective markers that may be used in CO intoxication. Especially lactate clearance may provide valuable information in predicting the need for HBOT and assessing treatment efficacy as a monitorization marker.
Authors and Affiliations
Seda Dağar, Emine Emektar, Hüseyin Uzunosmanoğlu, Şeref Kerem Çorbacıoğlu, Özge Öztekin, Yunsur Çevik
Keywords
Related Articles
- EP ID EP675980
- DOI 10.4274/imj.galenos.2019.10170
- Views 162
- Downloads 0
The Importance of Simultaneous Surgical and Endoscopic Polypectomies in Peutz-Jeghers Syndrome: A Case Report
Peutz-Jeghers syndrome may be presented with gastrointestinal and extra-intestinal malignancies. Herein, we report a case of Peutz-Jeghers syndrome with a malignant intestinal polyp accompanied by synchronous multiple ha...
Neonatal Morbidity in Macrosomic Infants
Introduction: Macrosomy is defined as birth weight being over 4000 grams. Neonatal complications are common in macrosomic infants. In this study, we aimed to compare macrosomic infants with normal weighed infants in term...
Perinatal and Medical Risk Factors in Children with Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder or Specific Learning Disorder: Comparison Between Diagnostic Groups
Introduction: Epigenetic changes in the pathogenesis of neurodevelopmental disorders, including prenatal and early life exposures, are becoming as appealing as hereditary genes. This study aimed to investigate possible p...
Exposures Moved from Work to Home as a Public Health Hazard
There are numerous occupational pollutants originating from a wide variety of industrial areas and working environments. These pollutants can be brought inadvertently from workplace to home in various ways and may negati...
A Cross-sectional Study Evaluating Childhood Autism Awareness of Residents Otorhinolaryngology Department in İstanbul
Introduction: Otorhinolaryngology (ENT) physicians may be effective in the early diagnosis of autism spectrum disorder (ASD). The aim of this study was to investigate the awareness of ENT residents in İstanbul about reco...