Clinico-Laboratory Profile of Vitamin B Deficiency in Children
Journal Title: GCSMC Journal of Medical Sciences - Year 2016, Vol 5, Issue 2
Abstract
Introduction: Nutritional vitamin B deficiency is common in developing countries and has a wide range of 12 neurological and hematological presentations. Aim: To study the clinical features and laboratory findings of vitamin B deficiency in children and correlate the findings with the severity of deficiency. Materials and Methods: 12 52 children between the age group 1month-6 years presenting with anemia and vitamin B deficiency were included 12 in this study. Their clinical findings and laboratory parameters were evaluated and correlated with the severity of vitamin B deficiency. Results: Out of the 52 patients enrolled 23 (44.2%) were boys and 29 (55.8%) were girls. 12 75% of children were in the age group 6 months to 2 years. All came from the lower socio-economic class. Deficiency was seen in children who had been breastfed by vitamin B deficient mothers, on inadequate 12 complimentary feeding and those on vitamin B deficient diets. 32 (61.5%) patients had severe vitamin B 12 12 deficiency. Apart from pallor, hyper pigmentation of knuckles (100%), hypo pigmented hair (100%), delayed development milestones (75%), tremors (37.5%), failure to thrive (31.2%) and generalized hypotonia, (25%) were the common features associated with severe vitamin B deficiency . 91.7% of patients with severe anemia had 12 severe vitamin B deficiency. Thrombocytopenia, leucopenia, pancytopenia, and macrocytosis were more 12 common in severe deficiency. Conclusion: Vitamin B deficiency was more common in children between the age 12 group of 6 months to 2years belonging to the lower socioeconomic class on a diet deficient in vitamin B . 12 Hematological and neurological manifestations were more common in those with severe deficiency. Early diagnosis and treatment is important to prevent hematological complications and neurological impairment in these patients. Preventive measures like dietary management and vitaminB supplementation have to emphasize.
Authors and Affiliations
Anuya Chauhan, Gargi Pathak, Mausam Shah
Keywords
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