Clinico-Radiological Profiling of Combined Hepatocellular Carcinoma and Cholangiocarcinoma (Biphenotypic) Tumors
Journal Title: PARIPEX-Indian Journal of Research - Year 2016, Vol 5, Issue 6
Abstract
Background: Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is an uncommon primary liver malignancy and little is known about the clinical and imaging characteristics. Objective: To define the features of cHCC-CC on contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CT) in this study. Methods: 45 patients with pathologically proven cHCC-CC had undergone preoperative CEUS and 43 patients who had additional CT scan in our institution were studied for retrospective review of the imaging studies and clinical data. Results: cHCC-CC accounted for 6.4% of all primary liver malignancy. Enhancement pattern resembling cholangiocarcinoma (CC) was noted in 53.3% (24/45) of patients on CEUS and in 30.2% (13/43) of patients on CT. Enhancement pattern resembling hepatocellular carcinoma (HCC) was observed in 42.2% (19/45) of patients on CEUS and in 58.1% (25/43) of patients at CT. The percentage of tumors showing CC enhancement pattern (27.9%, 12/43) was comparable with that of tumors showing HCC enhancement pattern (44.2%, 19/43) on both CEUS and CT (p = 0.116). Conclusions: The cHCC-CC tumors display enhancement patterns resembling CC or HCC in comparable proportion on both CEUS and CT.
Authors and Affiliations
Dr Sandhya Kothari, Dr Nupur Kothari, Dr Nilesh Agrawal
Keywords
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