Clinicopathological and Immunohistochemical Study of Synovial Sarcoma: A Series of 42 Cases from Single Institution
Journal Title: Saudi Journal of Pathology and Microbiology - Year 2018, Vol 3, Issue 7
Abstract
Abstract:Synovial sarcoma is a translocation associated sarcoma characterized by SS18 – SSX1/2 fusion. It is one of the common adult soft tissue sarcomas predominantly affecting lower extremities. In resource poor settings, exact characterization by molecular methods may not be feasible always. In our study we attempted to study the clinical profile, histomorphology and immunoprofile of cases diagnosed as synovial sarcomas. Forty two cases diagnosed as synovial sarcomas based of presentation, histomorphology and immunopanel were analysed .The median age of presentation was 26 years with male to female ratio of 1.5:1. Majority of the sarcomas were of monophasic type (83%) with predominant hemangiopericytomatous pattern (67%) followed by fascicular pattern (48%). Tumor size was greater in adults older than 20 years when compared to younger age group. Tumors with large areas of calcification were seen with significantly low mitotic index. Keywords: Synovial sarcoma, monophasic type, HPC pattern, calcifications.
Authors and Affiliations
Deepthi B, Uppin SG
Keywords
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