Clinicopathological Study of Renal Function in Type 2 Diabetics in Ile-Ife, Southwest Nigeria
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 16, Issue 9
Abstract
Aims: To determine the prevalence and clinico-pathological correlates of diabetic nephropathy among type 2 diabetics in Southwest Nigeria. Study Design: Descriptive, cross-sectional. Place and Duration of Study: Renal Unit, Medicine Department, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Southwest Nigeria. Methodology: Percutaneous ultrasound-guided renal biopsy was carried out in 40 consenting type 2 diabetic adults out of 88 patients in stages 3 and 4 chronic kidney disease using the Kidney Disease Improving Global Outcomes classification. Results: Eighty eight (48.1%) of the one hundred and eighty three subjects with mean age of 58.05(±6.10) years had clinical Diabetic Nephropathy. The duration of diabetes was 9.55(±4.1) years. Median protein excretion was 0.55 g/day. Mean estimated Glomerular Filtration Rate was 45.1(±12) ml/min. Thirty nine renal (97.5%) tissues showed glomerular basement membrane thickening. There was a positive correlation between the systolic blood pressure and severity of glomerular lesions (r=0.480, p=0.002), interstitial changes (p=0.602, r<0.001) and vascular lesions (0.429, 0.006). The diastolic blood pressure correlated with glomerular lesions (r=0.500, p=0.001), interstitial changes (0.479, 0.002), vascular lesions (p=0.431, r=0.006), nodular glomerulosclerosis (r=0.333, p=0.036) and diffuse glomerulosclerosis (r=0.372, p=0.018). Urinary protein excretion correlated with severity of glomerular lesions (r=0.457, p=0.003), vascular changes (r=0.483, p=0.002) and diffuse glomerulosclerosis (r=0.407, p=0.009). Diabetic retinopathy correlated positively with severity of glomerular lesion (r=0.406, p=0.009) and diffuse glomerulosclerosis (r=0.547, p<0.001). Conclusion: The prevalence of diabetic nephropathy among type 2 diabetics in Ile-Ife is high. Glomerular basement membrane thickening was the most prevalent renal pathology. There was a positive correlation between blood pressure, protein excretion, retinopathy and renal histology.
Authors and Affiliations
Akinbodewa Ayodeji Akinwumi, Okunola Oluyomi, Adelusola A. Kayode, Sanusi Abubakr Abefe, Arogundade Fatiu Abiola, Ikem T. Rosemary, Akinsola Adewale
Keywords
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- EP ID EP341172
- DOI 10.9734/BJMMR/2016/27021
- Views 56
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