Clock genes, chronotypes and diseases.
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2009, Vol 1, Issue 1
Abstract
Many common diseases in humans (such as cancer, heart disease, diabetes mellitus or psychiatric disorders, such as depression) seem to be linked to disruptions of circadian cycles and to clock genes variation. It is unlikely that such diseases to be caused by a genetic variation within a single gene. They must be influenced by complex interactions among multiple genes, as well as environmental and lifestyle factors. Therefore, it is important to understand how the resulting perturbations in our circadian biology could affect our physiological processes and susceptibility to disease. Associations between the polymorphisms of the main components of the circadian molecular clock, circadian type (also known as diurnal preference or chronotype) and diseases are presented.
Authors and Affiliations
Bogdan Voinescu
Keywords
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