Clostridium difficile – emergent hospital flora
Journal Title: Revista de Medicină Militară - Year 2014, Vol 0, Issue 1
Abstract
Clostridium difficile (C. difficile) is a Gram-positive sporogenous bacillus strictly anaerobic, which in the last decade has became the most important anaerobic bacterium in nosocomial human pathology. Cl.dificile is the etiological agent of more than 20% of diarrhea postantibiotics, over 95% of pseudomembranous colitis and the first cause of nosocomial infectious diarrhea in adults. Although this bacterium usually colonizes the intestine of vertebrates (the normal microbiota), the toxinogenic strains (tcdA and tcdB) are pathogenic in the digestive tract. Given the excessive use of antibiotics and the increased spores resistance, it is possible an environment contamination, with strains which may already be resistant to antibiotics. The main causes of this infection are decreased resistance to antibiotic-induced colonization, contamination with a pathogenic strain of Cl.difficile, secretion of A and/or B toxins and deficient immune response. Due to the increasing worldwide incidence of infections with C. difficile on one hand and to the discovery of new ways of transmitting the infection according with some studies regarding the genetic diversity of bacterium strains on the other hand, a new approach is necessary for C. difficile related topics.
Authors and Affiliations
Gabriela Dumitrescu, Viorel Ordeanu, Simona Bicheru, Lucia Ionescu, Diana Popescu, Marius Necsulescu
Keywords
Related Articles
- EP ID EP196320
- DOI -
- Views 87
- Downloads 0
About health, with hope
-
Brief notes about the Great War, Romanian military doctors and the Great Union
-
The role of contrast-enhanced ultrasound in risk assessment of carotid atheroma
Background and objective: Contrast-enhanced ultrasound, used to assess atherosclerotic carotid plaques, improves visualization of vessel wall irregularities and depicts intraplaque neovascularization. This article illust...
The complex implications of dermatoses specifically associated with pregnancy
Pregnancy-specific dermatoses are a heterogeneous group of inflammatory dermatoses associated exclusively with pregnancy. Although these dermatoses are rare, it raises problems in medical practice because of their appear...
One health
-