Co-Existence of Hereditary Pyrimidine 5’-Nucleotidase Deficiency and Heterozygous α-Thalassemia: A Case Presentation
Journal Title: Turkish Journal of Hematology - Year 2012, Vol 29, Issue 4
Abstract
To the Editor, Pyrimidine 5’-nucleotidase (P5N) is an intra-erythrocytic isoenzyme that catalyzes the dephosphorylation of pyrimidine ribonucleotides, which are the product of DNA catabolism. A reduction in P5N reactivity leads to accumulation of pyrimidine products in erythrocytes, which increases its life span, resulting in hemolytic anemia and intense basophilic stippling [1].
Authors and Affiliations
A. Agapidou, S. Theodoridou, K. Tegos, E. Mandala, O. Karakasidou, B. Aletra, M. Alemayehou
Keywords
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- EP ID EP121991
- DOI 10.5505/tjh.2012.48642
- Views 84
- Downloads 0
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