Co-Existence of Malaria With Thrombocytopenia
Journal Title: Journal of Indus Medical College - Year 2019, Vol 2, Issue 2
Abstract
BACKGROUND: Malaria, especially in developing countries, is an important health problem. It is significant cause of mortality and morbidity, particularly in tropics. In this specific disorder, there are many haematological changes, including thrombocytopenia, anaemia, atypical lymphocytosis as well as rare intravascular coagulation. OBJECTIVE: Purpose of this study is to identify and evaluate the extent of different haematological variations, particularly additional findings of thrombocytopenia in a specific form of malaria. METHODS AND MATERIALS: This was an observational study carried out at Department of Pathology, Indus Medical College Hospital Tando Muhammad Khan, on patients attending the clinically suspected malaria outpatient and inpatient departments. Thin and thick peripheral smear slides for malarial parasites were developed and were stained with Leishman's stain, followed by antigen tests were also incorporated where possible. Total blood counts were used in other studies. RESULTS: 238 (28%) patients showed malaria parasites on peripheral blood film among the 850 patients with suspected malaria included. Male superiority of 2.01:1 was observed as compared to females. A total of 196 out of 238 patients had thrombocytopenia. Higher levels of thrombocytopenia were observed in P. Vivax (62.26%) is accompanied with Mixed-type Infection (21.42%) and Plasmodium falciparum (15.81%). CONCLUSION: The anaemia specifically with decreased count of platelets (thrombocytopenia) was observed specifically in Plasmodium vivax, accompanied with Plasmodium falciparum. Given that thrombocytopenia is linked with patients of malaria, as shown in current research, in patients having low platelet count and fever, the care of doctors should preserve malaria as one of the differential diagnoses.
Authors and Affiliations
Shahzad Ali Jiskani, Dolat Singh, Sikandar Ali Bhand, Qandeel Abbas Soomro, Ghulam Abbas Soomro, Khadim Hussain
Keywords
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