Co-occurrence of type 2 diabetes mellitus and thyroid metabolic disorders in Bangladeshi population
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 2
Abstract
Studies have found that diabetes and thyroid disorders tend to co-occur in patients. Although this co-occurrence have been observed mainly in type 1 diabetes mellitus (T1DM), thyroid dysfunctions also co-occur in type 2 diabetes mellitus (T2DM) to a significant level. In the present study, we have investigated different thyroid function markers in 50 T2DM patients and 50 healthy age-sex matched controls of an urban population with mean±SD age of 41.86±6.43 and 41.54±7.88 respectively. Fasting blood glucose (FBG) (13.34±2.52 vs. 4.45±0.53) as well as mean glycosylated hemoglobin, HbA1c (%) (13.15±1.81 vs. 4.49±0.644) were significantly (p<0.001) higher in T2DM patients than control subjects. We found that serum levels of thyroid stimulating hormone (TSH) (1.22±0.74 vs. 1.74±1.07; p<0.01) and free T3 (FT3) (0.99±0.24 vs. 2.74±0.75; p<0.001) were significantly lower in T2DM patients than that of control subjects. However, we did not find any significant difference in case of the serum levels of freeT4 (FT4) (15.42±2.90 vs. 15.61±2.98) between the T2DM patients and control subjects. We found that levels FBG and HbA1c were abnormally high and serum FT3 was abnormally low in T2DM patients. On the other hand, levels of TSH, FT4, anti-thyroglobulin (TG) and anti-thyroid peroxidase (TPO) were all almost within the normal range in T2DM patients. A significantly lower anti-TG level was found in T2DM patients than control (33.44±5.25 vs. 35.64±4.0; p<0.05). This study revealed a significant negative correlation of serum FT3 with FBG and HbA1c (r=-0.789**, p=0.000 and r=-0.820**, p=0.000 respectively) irrespective of the groups. Findings of the present study on a small size of Bangladeshi population indicate the possibility of low FT3 syndrome in T2DM patients in which thyroid autoimmunity was not related.
Authors and Affiliations
Hosne Ara Begum, Kazi Saiful Islam, Md Riazul Hossen, Md. Monirujjaman, Sohel Ahmed
Keywords
Related Articles
- EP ID EP374249
- DOI -
- Views 60
- Downloads 0
A Study on Knowledge, Attitude and Practice (KAP) of Universal Precautions in The Nursing Staff of Tertiary care Hospital
Healthcare Associated Infection (HCAI) is the major cause of morbidity and mortality in hospital based settings; with nosocomial infections and their control creating a world-wide challenge. This also adds to the burden...
A Comparative Study between the Fresh Frozen Plasma and Local Steroid Infiltration in the Treatment of Plantar Fasciitis
The treatment for plantar fasciitis was local steroid infiltration since many years, but recently there is a shift towards fresh frozen plasma infiltration. Hence a comparative study was done between the two methods of t...
Prevalence of Skin Diseases in Rural Kashmir: A community based survey
Abstract: Skin diseases are one of the most common health problems. The objectives of this study are to determine the prevalence of skin diseases in a rural community. A community survey was conducted in a rural locality...
Grading of Brain Contusions by Modified Method: An Autopsy Study
Quantification and analysis of brain contusion was initially done in 1970’s followed by 2005. They derived brain contusion index based on parenchymal depth and surface distribution of contusion over brain. We conducted t...
Severe Trauma Admitted to Resuscitation Room at Mohammed VI University Hosptital - Marrakesh: Epidemiological, Clinical and Prognostic Aspects
By analyzing 175 cases of severe trauma admitted to resuscitation room at MOHAMMED VI University Hospital in Marrakesh, between 1 June 2016 and 31 May 2017, this study aims to describe epidemiological characteristics, so...