Coagulation Parameters in Pre-eclamptic and Eclamptic Patients - A Comparative Study of 90 Cases
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 8
Abstract
Introduction: Pregnancy Induced Hypertension (PIH) is one of the most common disorders seen in human pregnancies. In roughly half of the cases the disorder progresses into pre-eclampsia, a dangerous condition that can prove fatal to expectant mothers. Early assessment of severity of pre-eclampsia and eclampsia is necessary to prevent maternal and fetal morbidity and mortality. Hence, this study was undertaken with the objective to compare the coagulation parameters of women with pre-eclampsia and eclampsia. Material and Methods: Total 90 PIH cases in their third trimester of pregnancy comprising of 30 Mild Pre-eclampsia, 30 Severe Pre-eclampsia and 30 Eclampsia patients were enrolled for the study. Coagulation parameters such as BT, CT, PT, aPTT, platelet count were studied in these patients. Data were analyzed using MS Excel 2007 and GraphPad Prism 7. Results: There was statistically significant increase in the BT and aPTT with increase in the severity. Although CT and PT increase with the severity of PIH, it was not found to be statistically significant. Platelet count decreases significantly with increase in the severity. Conclusion: The abnormalities pertaining to coagulation parameters in PIH indicate the impending intravascular coagulation.
Authors and Affiliations
Upam Kr. Sharma, Reena Kouli, Ramesh Sonowal, Projnan Saikia
Keywords
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