Cognitive status in hypothyroid patients before and after attainment of euthyroidstate: A prospective study at tertiary care centre
Journal Title: Medpulse International Journal of Physiology - Year 2018, Vol 7, Issue 3
Abstract
Background: Thyroid hormones have profound effects on the central nervous system and the consequences of overt hypothyroidism are well known. In contrast, there is less evidence regarding cognitive effects of subclinical hypothyroidism. Objectives: To study the association of cognitive function with subclinical hypothyroidism. Methology: Total 56 participants who met the criteria for subclinical hypothyroidism included. Serum TSH, free T3 and free T4 were measured. Cognitive functions were assessed by using Folstein Mini Mental Examination MMSE(Mini Mental State Examination), DSST(Digit Symbol Substitution Test), LCT(Letter Cancellation Task),TMT tests(Trail making test) Results: Difference between serum fT3, fT4 and TSH levels of the patients atdiagnosis and after treatment was found to be significant. The MMSE score, error hits of DSST and LCT were found significantly higher (P<0.001) and negative correlation with TSH level and MMSE score. Conclusions: Prevalence of cognitive impairment was significantly higher in subclinical hypothyroidism as compared to controls.
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