Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains
Journal Title: Medical Science and Discovery - Year 2018, Vol 5, Issue 2
Abstract
Objective: The most important problem in the treatment of nosocomial Acinetobacter baumannii (A. baumannii) infections which is increasingly seen in recent years is that almost all strains are resistant to many antibiotics, including carbapenems, and that the extinction of antibiotic options to be used in treatment. This leads the clinicians to new treatment options and suggests the use of combined antibiotics to achieve success in both the treatment of multi-drug-resistant A. baumannii (MDRAB) infections as well as to prevent resistance development. We investigated the in vitro activity of colistin in combination with vancomycin, linezolid or daptomycin against MDRAB to determine whether these combinations would be considered for clinical use. . Methods: The fractional inhibitory concentration (FIC) index was used to determine the antibiotic combination effects and to evaluate the effect of antibiotic combinations on the bacteria. Results: MIC values of colistin/vancomycin, colistin/linezolid, and colistin/daptomycin in 10 strains (33.3%) gave similar results. Twenty strains gave different MIC results according to antibiotics. The colistin/daptomycin antagonistic ratio was high when the colistin/vancomycin synergy ratio was high compared to the others. Conclusion: Antibiotic combinations can be used as an alternative treatment approach in multi-drug resistant A. baumannii infections.
Authors and Affiliations
Arzu Irvem
Keywords
Related Articles
- EP ID EP520715
- DOI 10.17546/msd.391234
- Views 40
- Downloads 0
Thyrotoxicosis due to functioning metastatic follicular thyroid cancer
Thyrotoxicosis is a common condition associated with excess circulating thyroid hormones. Rarely, thyrotoxicosis can be developing due to functioning metastatic thyroid carcinoma. Most of patients with functional thyroid...
Ecthyma Gangrenosum in a Pediatric Patient and Review of the Literature
Erythema Gangrenosum (EG), is an infective lesion of skin, and mucous membranes typically occurring in patients with chronic disease or immunocompromised patients. İt is a very rarely seen vasculitis with a potentially p...
Evaluation of thiol/disulfide homeostasis in patients with a first episode of major depressive disorder
Objective: The aim of this study was to investigate the role of dynamic thiol-disulfide homeostasis as a new oxidative stress parameter in patients with major depressive disorder (MDD). Material and Meth...
A retrospective study for the effect of local ozone injection for treatment of musculoskeletal disorders
Objective: Aim of this study is to examine the effect of local ozone application on pain in patients who applied to physical medicine and rehabilitation outpatient clinic with knee, shoulder and back pain pr...
Complete heart block and acute inferior myocardial infarction due to generalized vasospasm
Sixtyone years old female patient had applied to emergency department with chest pain. Her ECG taken was compliant with acute inferior myocardial infarction and complete heart block. In her coronary angiography (CAG), th...