Combination of cinacalcet, calcitriol, and lanthanum carbonate in treatment of secondary hyperparathyroidism in uremia under hemodialysis
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 9
Abstract
Objective To observe the efficacy of combined treatment with cinacalcet, calcitriol, and lanthanum carbonate in uremia patients undergoing hemodialysis (HD) with secondary hyperparathyroidism (SHPT). Methods From January 2020 to December 2022, 80 uremia patients under HD with SHPT treated at Huangshan City People's Hospital were selected. They were randomly divided into the control group (40 cases, treated with calcitriol) and the study group (40 cases, treated with a combination of cinacalcet, calcitriol, and lanthanum carbonate). The calcium-phosphorus product, intact parathyroid hormone (iPTH), parathyroid volume, and carotid intima-media thickness (IMT), as well as adverse reactions, were compared between the two groups. Results Compared with before treatment, both groups showed a decrease in calcium-phosphorus product and iPTH after 1, 3, and 6 months of treatment (P＜0.05). Moreover, compared with the control group, the study group had lower calcium-phosphorus product and iPTH after 1, 3, and 6 months of treatment (P＜0.05). Compared with before treatment, both groups showed a reduction in parathyroid volume after 1, 3, and 6 months of treatment (P＜0.05). The study group also showed a reduction in carotid IMT after 3 and 6 months of treatment (P＜0.05), while the control group showed a reduction in IMT after 6 months of treatment (P＜0.05). Furthermore, compared with the control group, the study group had lower parathyroid volume and IMT after 3 and 6 months of treatment (P＜0.05). The incidence of adverse reactions in the study group was 17.50%, which was not significantly different from the 15.00% in the control group (χ2=0.092, P=0.762). Conclusion For uremia patients under HD accompanied by SHPT, combined treatment of cinacalcet, calcitriol, and lanthanum carbonate can improve calcium and phosphorus metabolism, regulate iPTH, reduce parathyroid volume and the risk of carotid atherosclerosis, without increasing adverse reactions.
Authors and Affiliations
WANG Chengjun , WANG Hong, WAN Jiakui, SHAO Jue
Keywords
Related Articles
- EP ID EP745465
- DOI 10.13429/j.cnki.cjcr.2024.09.018
- Views 25
- Downloads 0
Correlation between spot sign on dual-energy CT angiography and risk of hematoma enlargement in patients with hypertensive intracerebral hemorrhage
"<b>Objective</b> To investigate the correlation between spot sign (SS) on energy computed tomography angiography (CTA) and the risk of hematoma enlargement (HE) in patients with hypertensive intracerebral hemorrhage (HI...
Effects of laparoscopic sleeve gastrectomy on sex hormones in male patients with obesity
"<b>Objective</b> To evaluate the changes in sex hormone levels in male patients with obesity after receiving laparoscopic sleeve gastrectomy (LSG). <b>Methods</b> Forty-three male obese patients who received LSG at th...
Meta-analysis of incidence and risk factors of immune checkpoint inhibitor-associated pneumonia in patients with lung cancer
<b>Objective</b> To systematically evaluate the incidence and risk factors of immune checkpoint inhibitor-associated pneumonia (CIP) in patients with lung cancer. <b>Methods</b> The literature evaluating the incidenc...
Correlation between serum manganese and non-alcoholic fatty liver disease
Objective To investigate the relationship between serum manganese (Mn) levels and non-alcoholic fatty liver disease (NAFLD) in individuals of different genders. Methods Participants aged 18 years or older from the Nation...
Comparison of clinical efficacy between laparoscopic total gastrectomy and proximal gastrectomy in the treatment of adenocarcinoma of esophagogastric junction
<b>Objective</b> To compare the advantages and disadvantages of two different resection margins by observing the clinical efficacy of laparoscopic total gastrectomy (TG) and proximal gastrectomy(PG) for radical resection...