Combined BIS and Serum Neuron Specific Enolase in the predictive value of cardiopulmonary resuscitation patients.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Objective To evaluate the prognostic value of the bispectral index (BIS)and neuron-specific enolase (NSE) in patient with cardiopulmonary resuscitationpatients. Methods Forty-four patients with restoration of spontaneous circulation (ROSC) after CPR were treated with MTH. The BIS values were recorded and the serum NSE was measured at: 24 h, 48 h, and 72 hours respectively after ICU admission. Neurological outcome was classified according to the Pittsburgh cerebral performance category (CPC 1 to 5) at 3 months after ICU discharge. Results Thirteen patients had agood neurological outcome with CPC score 1-3, and thirty-one patients had apoor neurological outcome with CPC 4-5 at 3 months. Compared with good prognosis group, the NSE values were significantly higher in the poor prognosis group on day 2 and day 3 after admission [48 h:( 77.0±11.4) vs. Cpc4-5: (38.2±23.9)ng/mL；72 h:(87.0±9.3) vs. Cpc4-5: (45.8±26.4)ng/mL,P＜0.05. NSE increased in the poor neurological outcome group at 48h and 72h, and decreased significantly in the good group at the same time[△NSE 24 h-48 h：(37.3±28.7)ng/mL vs.(-10.2±12.1)ng/mL；△NSE 48 h-72h：(5.4±13.2) ng/mL vs. (- 4.3±4.2 ng/mL), P<0.05]. Over the 72hof monitoring, the mean BIS values were lower in the poor prognosis group compared to the good prognosis group at 48 h [(39.2±24.1) vs. (78.0±12.4);72 h; (45.7±26.4) vs. (89.0±7.3), P＜0.05. Conclusions The values of BIS and NSE were effective prognostic indicators for the neurological outcome of patients with MTH after CPR.
Authors and Affiliations
Shashank Sharma, Ren Quo Qing, Yin Xiao Juan
Keywords
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- EP ID EP402373
- DOI 10.9790/0853-1710081318.
- Views 63
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