COMFA AND COMSIA STUDIES ON 6, 8-DIBROMO–4(3H)-QUINAZOLINONE DERIVATIVES FOR ANTI-BACTERIAL ACTIVITY AGAINST SALMONELLA TYPHIMURIUM
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
In order to explore the structure – activity relationship of quinazolinone moiety for anti-bacterial activity against Salmonella typhimurium, a series of 4(3H) – quinazolinone derivatives were subjected to Comparative molecular field analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) methods. The best models for CoMFA and CoMSIA had correlation coefficient of 0.905 & 0.868 and cross-validated correlation coefficient of 0.501 & 0.592 respectively. The information obtained from the above models might be useful in designing of quinazolinone moiety as potent anti-bacterial agents.
Authors and Affiliations
Rahul Dixit
Keywords
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