COMPARATIVE ANALYSIS OF RBC MEMBRANE FATTY ACIDS, PROTEINS AND GLYCOPHORIN IN PATIENTS WITH HETEROZYGOUS BETA THALASSEMIA AND IRON DEFICIENCY ANEMIA
Journal Title: Indian Journal of Clinical Biochemistry - Year 2006, Vol 21, Issue 2
Abstract
Membrane lipid and protein composition was compared in erythrocytes from iron deficiency anemia (IDA) and heterozygous beta thalassemia patients. The study was planned to correlate the influence of iron deficiency with the intrinsic defect of the heterozygous condition on the membrane structural integrity as well as to investigate whether there are differences in membrane changes between the two conditions. Results indicate high levels of saturated fatty acids and low unsaturated fatty acids in both disorders although arachidonic acid and the unsaturation index were lower in heterozygous thalassemia than IDA. Nevertheless, neither of the conditions provoked any alterations in membrane protein or glycophorin suggesting alterations in the lipid moiety only. Present findings indicate that irrespective to the etiology, both, iron deficiency and the heterozygous condition show a common pattern of lipid derangement, which may in turn result in increased membrane rigidity and decreased cellular deformability.
Authors and Affiliations
S. Sanghani, V. Haldankar
Keywords
Related Articles
- EP ID EP82440
- DOI -
- Views 131
- Downloads 0
COMPARATIVE STUDY ON LIPID PEROXIDATION AND ANTIOXIDANT VITAMINS E AND C IN FALCIPARUM AND VIVAX MALARIA
Reactive oxygen species are thought to be involved in the pathogenesis of Malaria. To assess the extent of oxidative stress, a study was conducted in patients with Plasmodium falciparum malaria and Plasmodium Vivax mal...
INTERNET RESOURCES AND BIOCHEMISTRY
The Internet is a massive expanding body of information, which is likely to play a significant role for clinical Biochemists and researchers in patient health care across the world. This expansion has been matched by a...
IMMUNE RESPONSE TO N-TERMINAL AND C-TERMINAL DELETION MUTANTS OF ASPERGILLUS FUMIGATUS MAJOR ALLERGEN ASP F 3
20 ABSTRACT The ubiquitous fungus Aspergillus fumigatus causes allergic rhinitis, asthma, sinusitis and allergic bronchopulmonary aspergillosis. A number of major allergens from A. fumigatus are purified, but their st...
THE USE OF LYSOSOMAL ENZYMURIA IN THE EARLY DETECTION AND MONITORING OF THE PROGRESSION OF DIABETIC NEPHROPATHY
Recent acquisitions on the early detection and monitoring of the progression of diabetic complications (nephropathy) using the techniques of enzymology (lysosomal enzymes) are reviewed. It appears that the kidney is th...
PROSTATE SPECIFIC ANTIGEN IN PATIENTS OF BENIGN PROSTATE HYPERTROPHY AND CARCINOMA PROSTATE
Prostate Specific Antigen (PSA) has emerged as the most applicable and important tumor marker for carcinoma prostate. In the present study PSA was determined in serum of healthy subjects, patients of benign prostate hy...