Comparative Effect of Cinnamon Essential Oil, Diclofenac and Morphine on Acute and Chronic Pain in Mice
Journal Title: International Journal of Medical Laboratory - Year 2016, Vol 3, Issue 2
Abstract
Backgrounds and Aims: Cinnamomum Zeylanicum is a medicinal herb used in Iranian traditional medicine as an analgesic spice, which its analgesic effect has been experimentally confirmed. Thus, this study was conducted to compare the antinociceptive effect of cinnamon essential oil (CEO) with those of Morphine and Diclofenac in mice. Materials and Methods: 80 male albino mice were selected and randomly divided into 10 groups: a normal control group received distilled water, 3 test groups received different doses of CEO, 3 positive control groups were under the effect of different doses of Morphine Sulfate and another 3 positive control groups underwent the effect of 3 different doses of Sodium Diclofenac. Hot plate test was used to assess acute pain and writhing test was applied to measure the chronic pain. Results: Hot plate test showed that response latency to painful heat and thereby the maximum possible effect was increased in groups receiving Morphine, Diclofenac and CEO as compared with the control group (p<0.05). In writhing test, Morphine, Diclofenac and CEO significantly reduced the severity of abdominal contractions in comparison with the control group. This pain relief in the group receiving 500 µg/ kg, of CEO at any time and for doses of 250 and 125 µg/ kg in the 2nd and 3rd periods was similar to groups receiving different doses of Morphine or Diclofenac. Conclusions: Our findings concluded that CEO possesses antinociceptive properties. Its potency in chronic pain inhibition was similar to Diclofenac, thoughits acute antinociceptive effect was reported to be less than Morphine.
Authors and Affiliations
Mohammad Hossein Dashti-R, Mohammad Davud Qane, Farzane Shefaie, Mohammadreza Nazemian Yazdu, Seyyed Majid Bagheri
Keywords
Related Articles
- EP ID EP212589
- DOI -
- Views 133
- Downloads 0
Prevalence of Aeroallergens and Food Allergens in Allergic Patients in Tehran, Iran
Background and Aims: Identification of different allergens is a major challenge in allergic diseases. Avoiding these allergens is known as one of the best types of treatment. The aim of this study is to determine the pre...
Evaluating the Serum Levels of Calcium, Chloride, Potassium and Sodium in the Stroke Patients
Backgrounds and Aims: Stroke incidence rate has increased during the past 2 decades. The question of whether calcium, chloride, potassium, sodium levels are associated with stroke has remained controversial. The present...
Tips and Tricks in Fluorescence In-situ Hybridization (FISH)- based Preimplantation Genetic Diagnosis /Screening (PGD/PGS)
As numerical and structural defects in chromosomes are an inevitable consequence of IVF, Pre-implantation genetic diagnosis and screening (PGD/PGS) methods are used for detecting abnormalities in embryos before implantat...
Profiling Glycated Hemoglobin Level, Lactate Dehydrogenase and Alkaline Phosphatase Activity in Gestational Diabetes Mellitus Obese Women and Compare Them with Each Other
Background and Aims: The aim of this study was profiling glycated hemoglobin (HbA1c) level, lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) activity in obese women with gestational diabetes mellitus (GDM) and...
Prevalence of qnr Genes in Extended-Spectrum β-Lactamase Producing Klebsiella pneumoniae Isolated from Clinical Urine Specimens in University Teaching Hospitals, Iran
Background and Aims: Extended-spectrum β-lactamase (ESBL) producing gram negative bacteria are resistant to penicillins, narrow and extended-spectrum cephalosporins, and aztreonam; also they are frequently resistant to t...