Comparative Efficacy and Safety of Ebastine 20 mg, Ebastine 10 mg and Levocetirizine 5 mg in Acute Urticaria
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 3
Abstract
Introduction: Acute and chronic urticaria can result in severely impaired quality of life from pruritus and associated sleep lessness, as well as anxiety and depression. Various treatment modalities are available out of which second generation non sedating H1 antihistamines e.g., fexofenadine, loratidine, desloratadine, cetirizine, levocetirizine, ebastine etc., are used as the first line treatment. Aim: To compare the safety and efficacy of ebastine 20 mg, ebastine 10 mg and levocetirizine 5 mg in the patients of urticaria Materials and Methods: A longitudinal study was conducted in dermatology Outpatient Department (OPD) of Adesh Institute of Medical Sciences and Research, Bathinda, India. A total of 150 patients between the age group 10-70 years, both men and women having urticaria were enrolled and divided into three groups of 50 each. Group A was given ebastine 20 mg OD, Group B was given ebastine 10 mg OD and Group C was given levocetirizine 5 mg OD. The patients were asked to scale their severity of disease over a period of follow up based on Urticarial Activity Score 7 (Uas7). Results: The mean age of patients was 32.82 years. The mean UAS 7 score at the end of 4th week was 1.08 with ebastine 20 mg, 1.98 with levocetirizine 5 mg and 3.98 with ebastine 10 mg. In group A, 40 out of 50 patients (i.e., 80%), in Group B 25 out of 50 (i.e., 50%) get UAS7=0 and in Group C, 35 (i.e., 70%) patients who got relieved of symptoms at the end of treatment. When the scores were redefined and categorized under relieved and not relieved, and comparison done between all three groups, then there was a significant difference in the number of patients getting relieved, with p<0.001 (highly significant). Levocetirizine 5 mg had shown more side effects like dryness of mouth and sedation as compare to ebastine irrespective of dosage. The comparison made between the number of patients developing side effects among the groups was highly significant (p<0.001) for all the side effects. Conclusion: Ebastine 20 mg is found to have superior efficacy for treatment of Urticaria as compared to ebastine 10 mg but with levocetirizine 5 mg the results were almost similar. Tolerability of ebastine 20 mg is similar to ebastine 10 mg but with levocetirizine 5 mg there were more side effects and less tolerability.
Authors and Affiliations
Vippan Goyal, Anu Gupta, Onam Gupta, Dhruvendra Lal, Manharan Gill
Keywords
Related Articles
- EP ID EP336707
- DOI 10.7860/JCDR/2017/23961.9550
- Views 100
- Downloads 0
Comparison of Induction Characteristics of two Anaesthetic Agents: Etomidate-lipuro and Propofol for Day Care Surgery
ABSTRACT Introduction: Induction of anaesthesia is the most critical stage of anaesthesia. Thus, an induction agent with less side effect should be used. Aim: To compare the newer formulation of Etomidate in lipid formul...
Stress Management Training among Mothers with Autistic Children Referred to Autism Centres in Tehran
Introduction: Parental mental health can be strongly influenced by a child with a disability such as autism. This disorder involves a wide range of behaviours and in particular social behaviours. Aim: To investigate the...
A 3-D Finite Element Analytical Study to Evaluate the Effects of Newer Variable Implant Thread Pattern in Different Bone Densities
Introduction: Success of dental implant treatment depends on number of patient related and procedure dependent parameters. Various studies have shown that bone quality and implant design are two important factors in the...
Study of Pupil Dilatation Characteristics in Patients from Southern India with a Single Drop of Topical Tropicamide-Phenylephrine
ABSTRACT Introduction: Dilatation of the pupil is essential for eye examinations and procedures, and when the characteristics are known it will help the clinical work flow. Tropicamide-Phenylephrine combination is the mo...
Phytotherapy in Streptococcus agalactiae: An Overview of the Medicinal Plants Effective against Streptococcus agalactiae
Streptococcus agalactiae is a spherical and Gram-positive bacterium that causes postpartum sepsis, endometritis, chorioamnionitis and premature delivery in pregnant women. The use of herbs and natural ingredients for the...