COMPARATIVE EFFICIENCY OF FORMULATION TECHNIQUES FOR DEVELOPMENT OF SALBUTAMOL SULPHATE LOADED LIPOSOMES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 2
Abstract
Present study investigated most efficient technique for the development of salbutamol sulphate loaded liposomes. Salbutamol sulphate is a selective β2 adrenoceptor agonist widely used in the treatment of bronchial asthma, chronic bronchitis and emphysema. Our work is mainly focused on in vitro studies of liposomal formulation encapsulated with salbutamol sulphate which may have high drug entrapment, sustained drug release and effective vesicle size. Drug loaded liposomes were prepared by ethanol injection and thin film hydration techniques using soyaphosphatidyl choline and cholesterol in various molar ratios. Liposomes were evaluated for vesicle size, entrapment efficiency, transmission electron microscopy, zeta potential and drug release parameters. The particle size of drug loaded liposomes prepared by ethanol injection technique was 423‐527 nm whereas it was 160-174.2 nm when prepared by thin film hydration technique. Zeta potential of liposomes prepared by thin film hydration technique was enough to stabilize over six months. Optimized batches of salbutamolsulphate loaded liposomal formulations prepared by ethanol injection and thin film hydration technique have shown drug release as 94.59 % and 88.03 %, respectively. On the basis of observed average particle size, percent drug entrapment and drug release profiles, thin film hydration technique was emerged as superior technique over ethanol injection technique.
Authors and Affiliations
Sandip Honmane , Sachin Salunkhe, Ashok Hajare , Neela Bhatia
Keywords
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- EP ID EP136457
- DOI 10.7897/2230-8407.050214
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