Comparative evaluation of antihypertensive effects of Ramipril vs. Losartan in patients with uncomplicated stage-1 hypertension
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 6
Abstract
Hypertension is responsible for high morbidity and mortality in cardiovascular diseases. As Ramipril and Losartan are important ones due to extensive use, fewer side effects, low cost & availability in market, study was aimed to evaluate antihypertensive effects, tolerability & compliances of Ramipril & Losartan in patients with uncomplicated stage-1 hypertension in suburban & rural population. A randomized, single blind, parallel & cross over study was conducted in Medicine OPD of a tertiary care hospital for period of 12 months. Patients of both sexes, aged 25-60 years, with uncomplicated stage-1 hypertension were included. Patients with hypertension were checked for systolic blood pressure (SBP) / diastolic blood pressure (DBP) in sitting posture. Patients were randomly selected into 2 groups: group-A received tab. Ramipril (5 mg/day) & group-B received tab. Losartan (50 mg/day) at start of treatment, followed by wash-out period & then Losartan was given to group-A & ramipril to group-B. Paired t test applied between groups.
Authors and Affiliations
Vivek Das| MD, Department of Pharmacology, Burdwan Medical College & Hospital, Burdwan, Kolkata, India, Tanima Saha*| MBBS, MD PGT, Department of Pharmacology, Burdwan Medical College & Hospital, Burdwan, Kolkata, India, Himangshu Mahato| MBBS, MD PGT, Department of Pharmacology, Burdwan Medical College & Hospital, Burdwan, Kolkata, India, Swati Bhattacharyya| Associate Professor, Department of Pharmacology, R.G.Kar Medical College & Hospital, Burdwan, Kolkata, India, Supreeti Biswas| Professor & HOD, Department of Pharmacology, Burdwan Medical College & Hospital, Burdwan, Kolkata, India, M. R. Khandakar| Professor & HOD, Department of Medicine, COM & SDH, Burdwan, Kolkata, India
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