Comparative Evaluation of In-vitro Synergy Testing Methods in Carbapenem-Resistant Acinetobacter Species
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2019, Vol 9, Issue 1
Abstract
Objective: There is an increasing incidence of Acinetobacter species causing serious hospital acquired infections such as blood stream infections (BSI), catheter associated urinary tract infections (CAUTI) and lower respiratory tract infections(LRTI) with high mortality rate of 30-75% in patients having long hospital stay especially in critical care units (CCUs). During the past decade, multi drug resistant Acinetobacter isolates have presented a real challenge to clinicians and are posing difficulties in treatment. Carbapenem-resistant Acinetobacter species particularly A. baumannii, represent a growing public health concern, since they often confer resistance to other critically important antimicrobials. Methodology: In the present study, various antibiotic combinations such as colistin + meropenem, imipenem + tigecycline, polymyxin B + azithromycin and doripenem + sulbactam are used for MDR Acinetobacter infections and tested for in-vitro combination test by Epsilometric test and Broth Micro dilution and confirmation done by time kill assay. Results: We found synergistic results with all three methods used in study with three combinations significantly (p<0.05) but with one combination i.e. doripenem+sulbactam, synergy found only with Etest not with MCB and time kill assay (p~0.069). Conclusions: We have also observed and compared outcome of the patients with respect to the treatment received during hospital stay, but we did not found significant difference between two groups, (two drug regimen & three drug regimen) regarding their mortality. J Microbiol Infect Dis 2019; 9(1): 23-33.
Authors and Affiliations
Ranu Soni, Varsha Gupta, Satinder Gombar, Jagdish Chander, Priya Datta
Keywords
Related Articles
- EP ID EP652130
- DOI 10.5799/jmid.537162
- Views 124
- Downloads 0
High imported malaria incidence at a Moroccon military hospital
Objective:To evaluate the importance of imported malaria at the Moulay Ismail Military Hospital of Meknes, we have led a descriptive study of the epidemiological, clinical, biological and evolutionary characteristics of...
Legionella pnömonisi tedavisi sırasında ortaya çıkan serebellar tutulum: Bir vaka sunumu
Lejyoner hastalığı farklı klinik tablolar ile karşımıza çıkabilmektedir. Bu vakada toplumdan kazanılmış Lejyonella pnömonisi tedavisi görmekte olan sağlıklı bir kadın hastanın, tedavisi sırasında ciddi akut solunum sıkı...
Bir yenidoğanda Hiperimmunglobulin E sendromu: Olgu sunumu
Hiper-immunglobulin E sendromu (Job Sendromu), genellikle çok yüksek IgE (> 2000 IU/ml) seviyesi, şiddetli eozinofili, soğuk stafilokok cilt absesi ve pnömoni gibi tekrarlayan enfeksiyonlar, egzama, skolyoz, eklem hi...
Epidemiology and Antimicrobial Susceptibility of Anaerobic Bloodstream Infections: A 10 Years Study
Epidemiology and Antimicrobial Susceptibility of Anaerobic Bloodstream Infections: A 10 Years Study Nadeem Sajjad Raja Department of Microbiology, East Sussex Healthcare Trust, Hastings, England, UK ABSTRACT Objective:...
Treatment of Mucormycosis with Liposomal Amphotericin B, Posaconazole and Deferasirox: A Case Report
In this paper, we present a 69 years old diabetic patient with mucormycosis who was succesfully treated with liposomal amphotericin B (LAMB), posaconazole and deferasirox despite having no adequate surgery. Th...