COMPARATIVE IN-VITRO EVALUATION OF SOME COMMERCIAL BRANDS OF METFORMIN TABLETS MARKETED IN TRIPOLI-LIBYA
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 6
Abstract
The availability of several brands of Metformin tablets in Libyan pharmacies today places health practitioners in a problem of generic substitution. The aim of the present study was the evaluation and comparison between six different Metformin 500 mg brands, which are commercially available in the Libyan market produced by various pharmaceutical companies with different trade names. The physicochemical equivalence of six brands of Metformin tablets were investigated through the evaluation of both official and non-official standards according to the British Pharmacopoeia including uniformity of weight, thickness, hardness, disintegration time, drug content as well as dissolution rate. Acceptable external features as well as uniformity in diameter and thickness revealed for all the tablets. The entire brands complied with the official specifications for uniformity of weight where no tablet showed a deviation more than ±5%. Brands B, C, F had the highest crushing strength and highest disintegration time compared to the other brands. All the Six brands could be regarded as bioequivalent and therefore can be interchanged in the clinical practice. This sort of study is good indicator for the evaluation of the idealness of commercial products.
Authors and Affiliations
Dr. Tamader Y. Elghnimi
Keywords
Related Articles
- EP ID EP670968
- DOI -
- Views 191
- Downloads 0
MOLECULAR DETECTION OF CHLAMYDIA TRACHOMATIS INFECTION IN INFERTILE AND PREGNANT WOMEN ATTENDING ASSISSTED CONCEPTION CLINICS IN PORT HARCOURT, NIGERIA
Chlamydia trachomatis (CT) infections remain a leading sexually transmitted disease throughout the world and studies have linked this infection to adverse pregnancy, female infertility and poor outcomes in infant health....
SCREENING OF MALARIA PARASITES AMONG BLOOD BANK DONORS IN KOSTI TEACHING HOSPITAL, WHITE NILE STATE, SUDAN
Introduction: Malaria transmitted through blood transfusion occurring in malaria has been reported and documented endemic areas leading to severe illness for the recipients. Methods: Hundred blood donors were enrolled, 2...
SEQUENCE ALIGNMENT
A sequence alignment is a way of arranging the sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence of functional, structural, or evolutionary relationships between the sequences....
PHYSICOCHEMICAL CHARACTERIZATION OF BUDESONIDE FOR NANOPARTICLES PREPARATION.
Preformulation studies and characterization are known as a special fundamental Physico-chemical properties of the drug such as drug solubility, stability, melting point, and drug partitioning. Preformulation studies can...
ANTIBACTERIAL ACTIVITY FROM ETHANOLIC EXTRACT KARAS (AQUILARIA SP.) LEAVES AGAINST PATHOGENIC BACTERIA
Aquilaria microcarpa Baill. and Aquilaria malacanecis Lamk. are group of gaharu producing plants species that are widely cultivated in Indonesia, especially in West Borneo. Based on the empirical data the Aquilaria sp. l...