Comparative investigation to analyse the critical role of NFE2L2 gene in heavy metal induced toxicity through in silico approaches
Journal Title: Environmental Health Engineering and Management Journal - Year 2022, Vol 9, Issue 1
Abstract
Background: Accumulation of heavy metals like copper, nickel, arsenic, cobalt, and cadmium are increasing day by day. Accumulation of these heavy metals poses serious threats to human health. Elemental toxicity percentage has been found to be increased day-by-day and creating different minor to major problems from tissue to the gene level. Different important gene expressions are altered due to the contamination of such heavy metals. The present study aimed to identify a common target gene that is involved in the toxicity of major heavy metals and to study the major impact of the gene on the concerned biological system. Methods: In the progression of the work, major genes involved in copper, nickel, arsenic, cobalt, and cadmium toxicity were listed through intense data curation, and a pathway showing the correlation and physical interaction of all the genes that were constructed using in-silico tools STRING and Gene Mania database. Further, functional and expression analysis of the discovered gene was done using in-silico tools like genome-wide association study (GWAS), genotype-tissue expression (GTEx), and RegulomeDB. Results: According to the network analysis, NFE2L2 was recognized as a common target involved in the above-mentioned heavy metals toxicity. Expression analysis revealed that the highest expression of NFE2L2 was observed in tissues of oesophagus, ovary, bladder, vagina, thyroid, and skin. Detailed investigation at the pathway level revealed that the involvement was importantly observed in immunodeficiency and developmental delay. Conclusion: The study opened a wide vision that the major target of such toxicants is various pathways of neurobiological distress and biological processes, and hence, it can be considered as a susceptible target for heavy metals-induced toxicity.
Authors and Affiliations
Prekshi Garg,Neha Srivastava,Prachi Srivastava,
Keywords
Related Articles
- EP ID EP701590
- DOI 10.34172/EHEM.2022.05
- Views 115
- Downloads 1
Optimization and evaluation of the process variable’s effect on color and turbidity removal from coffee processing wastewater: Using a photoelectrochemical oxidation process
Background: Coffee is the foundation of Ethiopia’s economy, but the wastewater generated by coffee processing cannot be properly treated, therefore, causing various environmental problems. Methods: In this research, el...
Moisture-proof masks as a potential source to prevent COVID-19 during the rainy season
This article has no abstract
Assessment of aflatoxin exposure using urine biomarker in pregnant and non-pregnant women in Yazd, Center of Iran
Background: Aflatoxins (AFs) are one of the most prevalent toxins, which long-term exposure to them could be a risk factor for liver cancer. AFM1 is the hydroxylated metabolite of AFB1, therefore, the presence of AFM1 in...
Assessment of pollution and ecological risk of heavy metals in the sediments of the western coast of Persian Gulf: A case study in Dayer port
Background: In recent years, the pollution of heavy metals in the beaches has been noticed due to the increase of human activities. This study aimed to evaluate heavy metal pollution, its ecological risk, and possible...
Techno-economic assessment of recycling acidic sludge project of reprocessing industries to value-added gaseous products using Plasmatron
Background: Plasmatron is a hydrocarbon reformer of fuels and heavy oil sludge with high efficiency in gasification operation. The gasification of acidic sludge (AS) was investigated to assess the technical and financi...