Comparative polyphenol contents, free radical scavenging properties and effects on adipogenesis of Chorisia Chodatii and Chorisia Speciosa
Journal Title: Journal of Herbal Drugs - Year 2015, Vol 5, Issue 4
Abstract
Background & Aim: Chorisia is an important Bombacaceous plant that is traditionally used for a variety of ailments. Due to its richness in several bioactive phytocompounds, some Chorisia species showed a wide range of important biological effects. Accordingly, the present work was undertaken to comparatively evaluate the antioxidant potential and effects on adipogenesis of Chorisia chodatii Hassl. and Chorisia speciosa A. St.-Hil. in relation to their phenolic contents. Experimental: Total polyphenol contents and free radical scavenging potentials of the total ethanol extracts of leaves, flowers, fruits and seeds of both species, in addition to four main fractions of their leaf and flower extracts, were evaluated using the Folin-Ciocalteu's method and the DPPH assay, respectively. Besides, their effects on adipogenesis were studied using the 3T3-L1 preadipocytes model. A phytochemical screening of their different phytoconstituents was also considered. Results & Discussion: Total ethanol extracts along with their successive fractions of various parts of both species caused a concentration-dependent induction of 3T3-L1 preadipocytes differentiation, but with a noticeable reduction of the size of the lipid droplets at the lower concentrations 5 and 10 µg/ml. In addition, these extracts showed a strong evidence of their richness in free radical scavengers. The ethyl acetate, aqueous and chloroform fractions of different plant parts exhibited the greatest effects on adipogenesis, substantial free radical scavenging properties and the highest polyphenol contents, respectively. Industrial and practical recommendations: Results collectively revealed that the observed effects of both Chorisia species on adipogenesis as well as their anti-radical properties are positively related to their pool of flavonoids and other phenolics. They also suggest their potential value in obesity-related disorders and for prevention of free radical mediated diseases. Further studies for investigating the molecular basis of their effects on adipogenesis accompanied by detailed phytochemical analysis, especially of their polar and flavonoids-rich extracts, will also be strongly recommended.
Authors and Affiliations
John Refaat; Samar Yehia Desoukey; Mahmoud Ahmed Ramadan; Mohamed Salah Kamel; Junkyu Han; Hiroko Isoda
Keywords
Related Articles
- EP ID EP23463
- DOI -
- Views 363
- Downloads 18
Regulation of Intestinal GLP-1 and GLUT2 genes underlie hypoglycemia in Desplatsia subericarpa (Bocq)-Fed Wistar Rats
Background & Aim: Indigenous people of West Africa use the wholeleaf of Desplatsia subericarpa (Bocq) in anti-diabetic soup delicacy. This study was designed to validate the anti-diabetic claims and delineating possibl...
Antioxidant activity of the extracts from Salvia officinalis, Brassica oleracea, Juglans regia, Melilotus officinalis, and Crataegus oxyacantha at different temperatures
Background & Aim: Medicinal plants can be a good replacement for common cancer treatment including chemotherapy, radiation therapy and surgery because they don’t have many side effects. The aim of this study was to inves...
Improvement of alizarin production by different biotic elicitors in Rubiatinctorum by elicitation-infiltration method
Background & Aim: Rubiatinctorum is one of the most well-known medicinal plants whose alizarin and other anthraquinones which are outstanding color agents with some trace of pharmaceutical properties are isolated from...
Study the ethno-veterinary of medicinal plants in Kerman province, Iran
Background & Aim: The aim of this research is investigation and familiarity with the important herbal drugs that have used for traditional curing of animal diseases in different areas of Kerman province, Iran. From a lon...
Evaluation of anti-leishmanial efficacy by extract of Artemisia auchery Boiss. on Leishmania major in Balb/c
Background & Aim: Cutaneous infection caused by protozoa the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries including Middle East, Africa and Latin America. In the abs...