Comparative Study between Esmolol and Xylocard for Attenuation of Pressor Responses during Laryngoscopy and Intubation
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 4
Abstract
Background: Cardiovascular complications are one of the most common causes of anesthesia-related morbidity and mortality.The present work was undertaken to compare the effect of lignocaine (Xylocard) with esmolol on blunting the hemodynamic responses to endotracheal intubation. Methods: Laryngoscopy and intubation was done within 15 to 20 seconds.In group I: Inj. Lignocaine (Xylocard) i.v. was administered 3 minutes before laryngoscopy and intubation.In group II: Inj. Esmolol i.v. was administered 3 minutes before laryngoscopy and intubation. Changes in heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) were measured before induction of general anesthesia (baseline), 1, 3, and 5 min after tracheal intubation. Results: The heart rate response between lignocaine (Xylocard) and esmolol was very significant at all times starting from 1 to 10 minutes (p £ 0.05) with esmolol showing a favorable response towards attenuation of heart rate. In systolic blood pressure, Esmolol group showed a better attenuation compared to lignocaine group (Xylocard) until 3 minutes post-laryngoscopy. Attenuation of diastolic blood pressure was significant with esmolol than with lignocaine (Xylocard) group until 3 minutes (p<0.05). In mean arterial pressure, Esmolol caused significant attenuation of pressor response (p<0.05) at 1 minute and 3 minute post-laryngoscopy. Conclusion: Esmolol is more efficient than lignocaine (Xylocard) in attenuating the sympathetic responses to laryngoscopy and intubation.Esmolol at a bolus dose of 1.5 mg/kg i.v. administered 3 minutes before laryngoscopy appears to be very effective and should be viewed as potential treatment strategy for attenuating hemodynamic changes during induction of anesthesia.
Authors and Affiliations
Vani N. V.
Keywords
Related Articles
- EP ID EP539059
- DOI 10.21088/ijaa.2349.8471.5418.21
- Views 70
- Downloads 0
A Comparative Study between Bupivacaine and Clonidine Combination versus Bupivacaine (Plain) for Brachial Plexus blocks using Supraclavicular Approach
Background: Brachial plexus block achieves ideal operating conditions by producing complete muscle relaxation, maintaining stable intra-operative hemodynamics and associated sympathetic block. Usage of adjuvant drugs alo...
Effectiveness of Dexamethasone as an Adjuvant to Local Anesthetic Mixture in Supraclavicular Brachial Plexus Block
Adjuvant drugs are used to prolong the analgesic effects of local anesthetics in regional nerve blocks. This study was done to show the efficacy of Dexamethasone as a potent adjuvant in Supraclavicular Brachial plexus bl...
Comparative Evaluation of Hyperbaric 0.5% Bupivacaine-Clonidine and only 0.5% Bupivacaine for Spinal Anaesthesia
Pain of any kind is distressing to the life style of human being and relief of pain becomes mandatory all the time. Intraoperative as well as postoperative pain is of concern as it results in morbidity and mortality. Pos...
Evaluation of Dexmedetomidine as an Additive to Ropivacaine for Popliteal Approach for Sciatic Nerve Block for Foot Surgeries
Introduction: Peripheral nerve blocks are used in varieties of surgical and diagnostic procedures. Various methods or approaches have been tried to prolong the duration of nerve blocks. Dexmedetomidine acts selectively o...
Direct Conventional Laryongoscopy versus Video Laryngoscopy
Objectives: To compare direct conventional laryngoscopy (DCL) and video laryngoscopy (VL) in patients with difficult airway and to assess whether video laryngoscopy is superior to direct conventional laryngoscopy in diff...