Comparative Study of Bupivacaine alone versus Bupivacaine and Dexmedetomidine for Spinal Anesthesia in Hysterectomies
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 12
Abstract
Introduction: The efficacy of local anesthetics in spinal anesthesia can be enhanced by using adjuvants like fentanyl, morphine, tramadol and α2-agonists like clonidine, dexmeditomidine so as to improve the postoperative patient comfort and satisfaction. Aim: The present study was designed to study the analgesic efficacy and side effects of adding dexmedetomidine to bupivacaine in spinal anesthesia for gynaecological surgeries i.e hysterectomies. Patients and Methods: In a prospective, randomized, double-blind study, after taking their informed consent, 60 patients were randomly divided into two groups of 30 each. Sub arachnoid block was given with 12.5 mg of 0.5% hyperbaric bupivacaine in group I (n = 30) and with 12.5 mg of 0.5% hyperbaric bupivacaine plus 5 μg of dexmedetomidine in group II (n = 30). The two groups were compared with respect to hemodynamic parameters, onset of sensory block to T10 and regression to S1, time to achieve Bromage 3 and regression to Bromage 0, duration of analgesia, number of doses and type of rescue analgesia required, and complications occurring in 24 h. Results: Significant difference was observed in relation to onset of sensory block [12.7 ± 1.015 min in group I and 6.84 ± 0.792 min in group II (P < 0.001)], total duration of sensory block [177.74 ± 28.573 min in group I and 353.36 ± 12.138 min in group II (P < 0.001)], total duration of motor block [146.94 ± 9.173 min in group I and 318.36 ± 9.374 min in group II (P < 0.001)], duration of analgesia [283.96 ± 11.165 min in group II and 126.34 ± 7.684 min in group I (P < 0.001)], and total number of doses of rescue analgesia required in 24 h [1.44 ± 0.501 in group II and 2.56 ± 0.675 in group I (P < 0.001)]. Conclusion: Addition of dexmedetomidine to bupivacaine in sub arachnoid block leads to early onset of sensory and motor block with prolonged duration, and patients remained pain free for a longer period with decreased demand for rescue analgesia in the postoperative period as compared with hyperbaric bupivacaine alone without addition of dexmeditomidine.
Authors and Affiliations
Lt Col (Dr) Ritu Grewal
Keywords
Related Articles
- EP ID EP520085
- DOI -
- Views 72
- Downloads 0
Etiological Spectrum of Neonates Presenting With Intestinal Obstruction at A Tertiary Care Centre
Introduction: Intestinal atresia is one of the most common cause of intestinal obstruction in neonates; with very few reported data from the developing countries. Objective: To describe the epidemiological distribution o...
Comparison of Ramosetron with Ondansetron for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Gynecological Surgery
Background: Ramosetron is a new selective 5-hydroxytryptamine type 3 (5HT3) receptor antagonist that reportedly has more potent antiemetic effects compared with other 5HT3 receptor antagonists. The purpose of this study...
Comparison of First Attempt Success Rate between Two Insertion Techniques of Proseal Laryngeal Mask Airway
Background: The Pro Seal laryngeal mask airway (ProSeal LMA) is a relatively new laryngeal mask device designed to improve ventilator characteristics and offer protection against aspiration and gastric insufflation. But...
HIV Serosurveillance Profile in Men Sex Men: Targeted Intervention Group
Background: HIV is the plague of the running century.It has changed the fate of our society.Emergence of HIV threatened the economical, developmental, social welfare and public health progress not only in India but also...
Erectile Dysfunction and Severity of Alcohol Dependence
Background: It was reported that long-term and high amount of alcohol consumption cause sexual dysfunction in men. Men with alcohol dependence (AD) commonly suffer from alcohol-induced sexual (erectile) dysfunction (ED)....