Comparative study of epidural bupivacaine 0.125% and combination of epidural bupivacaine with clonidine 2µg/kg for postoperative analgesia
Journal Title: Medpulse International Journal of Anesthesiology - Year 2017, Vol 8, Issue 1
Abstract
Background and Objectives: Epidural analgesia offers superior post operative pain relief compared with systemic drugs. In addition to improved pain control, epidural analgesia canimprove patient outcome by attenuating detrimental post operative stress. Clonidine, an alpha -2 receptor agonist, administered epidurally, is gaining popularity for its analgesic, sedative, sympatholytic properties. The present study was undertaken to compare and evaluate the analgesic efficacy of epidural bupivacaine and bupivacaine with clonidine. Materials and Methods: 60 patients of ASA I and II between the age group 20- 60 yrs of either sex undergoing abdominal, gynaecological and orthopedic surgeries under subarachnoid blockade were included. After the surgery was over and when the patients complained of pain or VAS > 4, they were allocated to receive either Group B - plain bupivacaine (0.125%) 10 ml (n=30), Group B + C - Clonidine 150 mcg (1ml) + 0.125% Bupivacaine 9ml (n=30). Data obtained were subjected to analysis using statistical software SPSS 20. Results: Onset of analgesia was statistically significant shorter in Group B+C than Group B (16.86±1.89 minutes vs 12.86±2.06 minutes ) with P value <0.05).Duration of analgesia was significantly longer in Group B+C than Group B (316.23±33.78 minutes vs 131.13±25.37 minutes ) with P value <0.001). 100% of patients were found asleep in Group B+C from 30min till 2.5hrs and in the Group B, no patient was found asleep. Conclusion: Epidural clonidine with bupivacaine significantly shortened the of onset of analgesia, provides good sedation, excellent and long duration of analgesia postoperatively.
Authors and Affiliations
J Jayaganesh, C S Prakash
Keywords
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- EP ID EP440562
- DOI 10.26611/1015819
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