Comparative Study Of Local Anaesthtic Action Of Bupivacaine With Standard Xyolocaine In Rabbits And Guniea Pigs.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 2
Abstract
Aims& objectives:The present study was designed to compare the onset and duration of action of two local anaesthetics bupivacaine with standard xylocaine in rabbits surface anaesthesia and guinea pigs infiltration anaesthesia . Materials & methods: 8 albino rabbits of either sex weighing 2.5-3kgs and 6 guniea pigs of either sex weighing 200 -300gms were selected and different procedures have been extensively used in this work. However no other test known provides all the information required, so that one must be prepared to apply several different tests, each useful because of the information it provides. surface anesthesia is used to indicate relative speed of onset of anesthesia, rather than duration, Statistical Analysis: All statistical tests carried out. Discrete valuable were compared on the basis of unpaired t-tests. P value was obtained (t=2.145) by chance is much less than 0.05 (p < 0.05), which is highly significant on Rabbits. P value was obtained (t=2.228) by chance is much less than 0. 05 (p < 0.05), which is highly significant on Guinea Pig. Results: The result both groups were compared and studied. In these both drugs Bupivacaine is present rapid on set and prolong duration of action. Conclusion: 1. Xylocaine shows the intermediate local anaesthetic action. 2. Bupivacaine shows the longer local anaesthetic action. 3. Xylocaine shows the slow on set and short duration of action. 4. Bupivacaine shows the earlier on set and long duration of action.
Authors and Affiliations
A. Viswashanthi, Dr. Gousebhasha, Dr. Maddala Rajitha
Keywords
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