Comparative Study of Oral Mifepristone and Endocervical Prostaglandins E2 Gel as Preinduction Cervical Ripening Agent in Parturition
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 3
Abstract
Introduction: The present day obstetrics calls for induction of labor for a myriad of obstetrical, medical, and fetal indications. We should only induce labor when we are sure that we can do better. The prostaglandins (PGs) and antiprogesterones have major role in labor induction. Aim: The aim is to evaluate the efficacy and safety of oral mifepristone and endocervical PGE2 gel in labor induction. Methods: To compare the efficacy of oral mifepristone and endocervical PGE2 gel as preinduction cervical ripening agents. 100 antenatal women were selected among which 50 women received 200 mg oral mifepristone and 50 women received 0.5 mg endocervical PGE2 gel. Results: Mean increase in Bishop score in mifepristone group is 5, whereas 36 in PGE2 gel group. Oxytocin requirement for augmentation in mifepristone group is 66%, whereas 78% in PGE2 gel group. Duration of 2nd and 3rd stage of labor was shorter in mifepristone group. Cesarean section rate was higher in PGE2 gel group 24% whereas in mifepristone was 6%. Maternal complications were similar in both groups. Neonatal intensive care unit admission was 18% in PGE2 gel group whereas 10% in mifepristone group. Conclusion: Oral mifepristone is very safe and an effective drug for preinduction cervical ripening. It is more effective in multigravida than primigravida.
Authors and Affiliations
B Arumugaselvi, S Sujathasenthil, Heber Anandan
Keywords
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