COMPARATIVE STUDY OF PREVALENCE OF H. PYLORI IN PATIENTS WITH FUNCTIONAL DYSPEPSIA IN ALCOHOLICS AND NON-ALCOHOLICS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 40
Abstract
BACKGROUND Helicobacter pylori and Alcohol use are important factors among the numerous factors associated with Functional Dyspepsia. The prevalence of functional dyspepsia and alcoholism is higher in India. This cross-sectional study was taken up to determine the association between Helicobacter pylori and Alcohol use among Functional Dyspepsia patients. MATERIALS AND METHODS Functional Dyspepsia symptoms were identified using Rome III BI criteria. Four gastric mucosal biopsies were taken from the antrum by endoscopy. Two of them were tested for H. pylori in the urease broth by the Rapid Urease Test (RUT) and rest 2 specimens were sent for histopathological examinations. Either the RUT biochemical test or the HPE test was considered positive for H. Pylori. Alcoholism and the severity assessed by DSM-questionnaire. RESULTS Seventy functional dyspepsia patients were included in this study and of them 35 were alcoholics and 35 were non-alcoholics. The prevalence of H. pylori in FD cases was significantly higher in non-alcoholics (82%) compared to alcoholics (28%) and this difference was statistically significant (p value < 0.05). On comparing the quantity of alcohol consumed, H. pylori was more prevalent (58%) in people who consume 91 to 160 gms of alcohol. This is higher in comparison with people who consume less alcohol in the range of 31 to 90 gms (13%). This difference is statistically significant (p < 0.001). CONCLUSION Alcoholism is found to be a protective factor against H. pylori infection among functional dyspepsia patients.
Authors and Affiliations
Bala Vignesh R, Kannan R, Manoj Karthik
Keywords
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- EP ID EP213287
- DOI 10.14260/Jemds/2017/688
- Views 69
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