Comparative study of sequential therapy versus standard triple therapy versus quinolone-based triple therapy for eradication of Helicobacter pylori infection
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2017, Vol 3, Issue 10
Abstract
Introduction: H. pylori is a gram-negative bacillus that has naturally colonized humans. Essentially all H. pylori– colonized persons have gastric tissue responses, but fewer than 15% develop associated illnesses such as peptic ulceration, gastric adenocarcinoma, or gastric lymphoma. Worldwide, more than 80% of duodenal ulcers and more than 60% of gastric ulcers are related to H. pylori colonization. Although H. pylori is susceptible to a wide range of antibiotics in vitro, monotherapy is not usually successful. Failure of monotherapy has prompted the development of multidrug regimens, the most successful of which are triple and quadruple combinations. Aims and Objectives: To compare efficacy of Sequential Therapy versus Standard Triple Therapy versus Quinolone-based Triple Therapy for eradication of Helicobacter Pylori infection. Methods: The study included 150 patients attending OPD / admitted in various wards of a tertiary care hospital diagnosed to be helicobacter pylori positive by rapid urease test, after obtaining informed consent. The patients were then be randomly divided into three groups each of 50, one had received Sequential Therapy, other triple therapy and third quinolone based therapy. Results and conclusion: Sequential therapy group had better eradication rates (90%) as compared to standard triple therapy group (86%) and fluroquinolone therapy group (82%) but results were not statistically significant when all three groups were compared together.
Authors and Affiliations
*Dr. Krishan kumar Oberoi, **Dr. Upasana
Keywords
Related Articles
- EP ID EP570667
- DOI 10.22192/ijcrms.2017.03.10.014
- Views 142
- Downloads 0
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