Comparative study of therapeutic efficacy of intralesional vitamin D3 versus intralesional purified protein derivative in the treatment of warts
Journal Title: IP Indian Journal of Clinical and Experimental Dermatology - Year 2018, Vol 4, Issue 3
Abstract
Introduction Warts are benign epidermal proliferations of skin and mucosa caused by human papilloma virus Destructive therapeutic modalities are limited by cost pain scarring Immunotherapy is a new modality which acts on enhancing cell mediated immunityObjective This study aims to evaluate and compare efficacy of intralesional vitamin D3 and purified protein derivative PPD in treatment of wartsMaterials and Methods It is a prospective hospital based comparative study among 40 patients with warts Patients were randomly and equally divided Group A patients were given intralesional vitamin D3 02ml of 15mgml into each wart and Group B patients were given intralesional PPD 02ml of 5TUml into each wart The injections were repeated every 2 weeks until complete clearance Decrease in size and number of lesions were evaluated and photographic record was maintained Patients were followed up after 3 months Unpaired t test was used for statistical analysisResults The study found that 14 out of 20 patients 70 of Group A showed complete response after 4 sessions and 6 patients 30 showed moderate response 17 out of 20 patients 85 of Group B showed complete response 2 patients 10 showed moderate response 1 patient 5 showed no response Recurrence was observed in 1 patient after 3 months who received vitamin D3 No serious adverse effects were observedConclusion Both vitamin D3 and PPD showed positive results with PPD having faster and better efficacy in treatment of multiple common wartsKeywords Immunotherapy Warts Intralesional Vitamin D3 Tuberculin purified protein derivative
Authors and Affiliations
Madhavi Latha Akula, Monisha Shetty, Vinma Shetty, Parag Patel, Ameen Basil
Keywords
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- EP ID EP488900
- DOI 10.18231/2581-4729.2018.0048
- Views 113
- Downloads 0
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